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Presentation type	E-poster
Title	Bilateral Diffuse Preretinal Deposits in a patient with diabetic tractional retinal detachments

Purpose	Report a rare case of diffuse preretinal deposits associated with a severe proliferative diabetic retinopathy in a 40yo patient and to synthesize existing literature regarding their nature and pathogenesis.
Methods	A single-case report alongside a literature review, analyzing reported etiologies, oct patterns and histological profiles of pds in non-infectious, proliferative, and inflammatory vitreoretinopathies.
Results	A 40-year-old male with autism presented with bilateral tractional retinal detachments due to severe proliferative diabetic retinopathy. Per operatively we discovered diffuse bilateral yellowish pds carpeting the mid-periphery alongside the vessels that were not visible before due to the detachments. On OCT the deposits presented as multifocal, hyperreflective nodular or dome-shaped located strictly along the vitreoretinal interface, adhering to the inner surface of the ILM. Morphologic patterns vaguely resemble the previously described “stalagmite-like precipitates”. Literature review reveals their presence in a multitude of conditions mainly inflammatory causes (1). Their biochemical composition consists of fibrin, macrophage aggregates and other cellular breakdown products originating from massive leaking of the inner blood-retinal barrier (2). While not being specific of any particular condition but rather of a variety of infectious and inflammatory causes, the pds have not explicitly been cited to be found in diabetic rp. In our case we found no other systemic conditions and during the vtx they were adherent to the retina and henceforth difficult to sample.
Conclusion	Those deposits are uncommon markers of inner blood-retinal barrier disruption and inflammation. In our patient, recognizing them prevents misdiagnosis as infectious or neoplastic entities
Conflict of interest	No

Authors 1

Last name	SAAB
Initials	C

Authors 2

Last name	LARUELLE
Initials	G

Authors 3

Last name	BUGHIN
Initials	A