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Presentation type	E-poster
Title	Photobiomodulation in Reticular Pseudodrusen-Associated Dry Age-Related Macular Degeneration: Effects on Geographic Atrophy, Photoreceptor Degeneration and Retinal Sensitivity

Purpose	Dry Age-Related Macular Degeneration (dAMD) is a leading cause of vision loss in the elderly. Limited interventions make sight preservation challenging, emphasising the need of treatments. This case report assesses photobiomodulation therapy (PBMT) in reticular pseudodrusen-associated dAMD, evaluating structural and functional changes following PBMT.
Methods	The patient underwent nine PBMT cycles over a 58-months using the Valeda PBMT device on the left eye only. They had two cycles per year, with a 17 month gap between the first two cycles due to the pandemic. Each cycle consisted of nine sessions, delivering 590nm amber, 660nm red, and 850nm near-infrared light over approximately nine minute sessions. Parameters were assessed before and after most cycles; Heidelberg optical coherence tomography (OCT) was used for macular imaging, with RetInSight AI software retrospectively calculating geographic atrophy (GA) and photoreceptor (PR) degeneration. Retinal sensitivity was measured with macular integrity assessment (MAIA).
Results	Over the 58 month period, GA area remained stable at a baseline of 0.2mm2 in the 6mm ETDRS macular region. PR degeneration increased slightly from a baseline of 0.3mm2 to 0.4mm2. Retinal sensitivity was preserved, decreasing by 0.3dB from 26.6dB to 26.3dB over this period.
Conclusion	Reticular pseudodrusen-associated dAMD is seen with faster progression and vision loss. This case highlights the potential of PBMT in its management. Further studies, including larger controlled studies, are needed to see if the findings are reproduceable and attributable to PBMT.
Conflict of interest	Yes
Details of conflicting interests	John Rose provides PBMT using the Valeda system as a fee-paying service. He has spoken about Valeda on behalf of Alcon at 100% Optical and other peer meetings.

Authors 1

Last name	MIRZA
Initials	M
Department	John Rose Eye Care
City	London

Authors 2

Last name	Rose
Initials	JR
Department	John Rose Eye Care
City	London