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This abstract is assigned to session AOB Free Papers 1

Presentation type	Oral presentation
Title	Ab externo Schlemm's canal surgery: efficacy and safety outcomes

Purpose	The purpose of this study was to conduct a literature review on the efficacy and safety of ab externo viscocanalostomy (VCS) and canaloplasty (CP) in glaucoma patients.
Methods	A literature search was conducted, following the PRISMA 2020 Statement criteria, in Medline (via Pubmed), Embase (Ovid), Web of Science (Clarivate Analytics) and Cochrane Library (Cochrane). Articles have been included based upon their relevance. Wherever possible, level of evidence (LOE) has been assessed by means of the Oxford Centre for Evidence-based Medicine Level of Evidence classification.
Results	This review includes a total of 25 articles providing data for 2717 subjects. The mean preoperative medicated IOP was 24.83 mmHg in the CP group and 36.22 mmHg in the VCS group. The mean postoperative IOP was 14.92 mmHg in the CP group and 15.17 mmHg in the VCS group at 36 months of follow-up. VCS and CP show a mean IOP reduction from baseline of 58,1% and 39,9% respectively and medication reduction of 81 % and 76,9% respectively after 36 months of follow-up. Perforation of the trabeculo-descemetic membrane (TDM) was reported in 5.39% and 8.24% of cases in the CP and VCS group respectively. (Micro)hyphaema was the most commonly reported postoperative event.
Conclusion	VCS and CP show a significant reduction in IOP and medication use. The incidence of complications seen in filtering surgery is minimised by the nonpenetrating and bleb-independent approach. With its efficacy and high safety profile Schlemm's canal surgery is a valuable alternative to penetrating glaucoma filtration surgery.
Conflict of interest	No

Authors 1

Last name	BATAILDE
Initials	G
Department	Department of Ophthalmology, University Hospitals UZ Leuven
City	Leuven