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Presentation type	E-poster
Title	BAP1 cancer syndrome: implications for ophthalmologists

Purpose	BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical skin and uveal melanocytic tumors and other neoplasms. In this abstract we illustrate a family with BAP1 cancer syndrome, and the screening for patients with BAP1 germline mutations.
Methods	Patient records review and general literature review
Results	A family with germline BAP1 mutation and 3 members with uveal melanoma will be illustrated. Besides, the general advice for BAP1 positive families is reviewed.
Conclusion	BAP1 germline gene mutations should be examined in all uveal melanoma patients < 40 years, associations with mesotheliomas and skin tumors. Also in patients with a positive family on melanomas.
Conflict of interest	No

Authors 1

Last name	MISSOTTEN
Initials	G
Department	University Hospitals Leuven, Catholic University.
City	Leuven

Authors 2

Last name	Vandenbempt
Initials	I
Department	University Hospitals Leuven, Catholic University.
City	Leuven

Authors 3

Last name	Van Calster
Initials	J
Department	University Hospitals Leuven, Catholic University
City	Leuven