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Title

Cancer-associated rethinopathy secondary to gallbladder carcinoma

Purpose	Presenting a case report of a patient with cancer-associated retinopathy (CAR) secondary to a gallbladder carcinoma.
Methods	The diagnosis of CAR was suspected on grounds of anamnesis, clinical features and technical investigations (VF, OCT, FF-ERG, PET-CT, immunofluorescence antibody screening). Initial treatment consisted of high dose corticosteroids (1mg/kg/day)
Results	A positive clinical evolution was found after treatment with high-dose corticoids with disappearance of uveitis symptoms and gradual improvement of visual acuity and VF.
Conclusion	CAR is a rare disease entity caused by auto-antibodies against retinal antigens. The disease is associated with a wide spectrum of malignancies. Clinical features are progressive VF narrowing, diminished visual acuity, macular edema, vitritis, fundus changes, photophobia, diminished color perception. Cortisone therapy with or without plasmapheresis can be considered as a first choice treatment. Corticoid saving immunosuppressive therapy and/or biologicals can be used as maintenance therapy. The long term prognosis is uncertain because further evolution is possible.
Conflict of interest	No

Authors 1

Last name	GOYVAERTS
Initials	K
Department	Universiteit Antwerpen
City	Wilrijk

Authors 2

Last name	VAN LINT
Initials	M
Department	Universitair Ziekenhuis Antwerpen
City	Edegem