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Title

Hyperspectral imaging and the retina: worth the wave?

Purpose	Hyperspectral imaging is gaining attention in biomedical research because it generates additional spectral information that can be used to study physiological and clinical processes. Several methods have been described, but an independent, systematic literature overview is lacking, especially in the field of ophthalmology.
Methods	A literature search has been conducted, following the PRISMA Statement 2009 criteria, in four large bibliographic databases. Articles have been included based upon their relevance. Wherever possible, risk of bias and quality have been assessed.
Results	Fifty-two articles have been withheld. Seven studies have been assessed by means of Newcastle-Ottawa Quality Assessment Scale (NOS), while Techniques based on Fourier analysis, liquid crystal tunable filters, tunable laser sources, dual-slit monochromators, dispersive prisms and gratings, computed tomography, fiber optics and Fabry-Perrot cavity filter covered complementary metal oxide semiconductor (CMOS) are being reported, all with variable acquisition time, spectral width, spectral and spatial resolution and experimental set-up. We performed a narrative synthesis and produced summary tables of findings of included papers because methodological heterogeneity and research topic precluded a meta-analysis.
Conclusion	The application in ophthalmology is still in its infancy. Most of the experiments have been performed in the field of retinal oximetry. Relatively small studies show promising results for hyperspectral imaging, e.g. in Alzheimer research. The true potential of this innovative technique remains to be unlocked.
Conflict of interest	No

Authors 1

Last name	VAN EIJGEN
Initials	J
Department	UZ Leuven/KU Leuven
City	Leuven

Authors 2

Last name	Lemmens
Initials	S
Department	UZ Leuven/KU Leuven/VITO
City	Leuven

Authors 3

Last name	Van Keer
Initials	K
Department	UZ Leuven/KU Leuven
City	Leuven

Authors 4

Last name	De Boever
Initials	P
Department	VITO
City	Mol

Authors 5

Last name	Stalmans
Initials	I
Department	UZ Leuven/KU Leuven
City	Leuven