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Title

Clinical characteristics and complications in intermediate uveitis: analysis of 15-years experience in a tertiary center for uveitis in Belgium

Purpose	To report the clinical characteristics and complications of intermediate uveitis (IU) in 83 patients in a tertiary referral center for uveitis in Belgium.
Methods	a retrospective cohort study of patients with IU attending the University Hospital of Ghent from 2002 till 2018.
Results	83 patients(152 eyes, 55,2% females) were included. Mean age at presentation was 27y. Mean follow-up was 103 months. The most common form was idiopathic(n=50), followed by pars planitis(n=13), multiple sclerosis(MS)(n=10), sarcoidosis(n=4), Lyme disease(n=3), tuberculosis-associated uveitis(n=2) and syphilis(n=1). Epiretinal membrane(ERM)(61,4%), cystoid macular edema(CME)(49,4%), cataract(30,1%), secondary glaucoma(13,2%) and retinoschisis(12%) were the most prevalent complications. CME and glaucoma were most sight-threatening. Main treatment indications were CME or severe vitreous inflammation. Treatment included local and systemic steroids, immunosuppressive agents and biologics next to antibiotics in infectious uveitis. Systemic treatment was indicated in case of visual acuity drop ≥ 2 lines and/or CME. More than half of the patients(n=55) received systemic treatment according to the Belgian Guidelines.
Conclusion	In our Belgian tertiary center IU was mostly idiopathic, followed by pars planitis and MS. With regard to our complications, systemic treatment was indicated in more than half of the patients proving that IU needs a strict follow-up and rarely achieves prolonged remission.
Conflict of interest	No

Authors 1

Last name	TACK
Initials	M
Department	Ghent Unversity Hospital
City	Gent

Authors 2

Last name	VANCLOOSTER
Initials	A
Department	Ghent University Hospital
City	Gent

Authors 3

Last name	SYS
Initials	C
Department	Ghent University Hospital
City	Gent

Authors 4

Last name	LEROY
Initials	BP
Department	Ghent University Hospital, Ghent University, Centre of Medical Genetics Ghent University Hospital
City	Gent

Authors 5

Last name	DE SCHRYVER
Initials	I
Department	Ghent University Hospital
City	Gent