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Title

OCT Angiography reveals a non-flow area enlargement in the choriocapillaris with increasing age

Purpose	To evaluate the relationship between age and both non-flow area and flow signal in the choriocapillaris of the macular region, as measured using optical coherence tomography angiography (OCTA).
Methods	87 eyes of 87 healthy volunteers were examined using a high-speed and high-resolution spectral-domain OCT XR Avanti system with a split-spectrum amplitude de-correlation angiography algorithm. Choriocapillaris images were analysed to determine the choriocapillaris decorrelation index (CCDI), flow voids greater than 10,000 µm2 (FV10000) and signal voids greater than 40,000 µm2 (FV40000).
Results	The mean patient age was 30.55 ± 14.59 years. Mean CCDI was 116.40 ± 5.64, mean FV10000 65.85 ± 7.75 and mean FV40000 36.87 ± 15.04. Correlations between age and respectively CCDI, FV10000 and FV40000 showed a moderate but significant correlation (r = -0.3545, p = 0.0008;r = 0.3626, p = 0.0006; r =0.3897, p = 0.0002).
Conclusion	Our results suggest an increase in non-flow areas with increasing age, which could explain the decrease in overall flow signal.
Conflict of interest	No

Authors 1

Last name	NELIS
Initials	P
Department	UKM, VUB
City	Muenster, Brussels

Authors 2

Last name	Müller
Initials	V
Department	UKM
City	Muenster

Authors 3

Last name	Mihailovic
Initials	N
Department	UKM
City	Muenster

Authors 4

Last name	Eter
Initials	N
Department	UKM
City	Muenster

Authors 5

Last name	Ten Tusscher
Initials	M
Department	VUB
City	Brussels

Authors 6

Last name	Alnawaiseh
Initials	M
Department	UKM
City	Muenster