Title | Comparing anterior segment optical coherence tomography and ultrasound biomicroscopy with histopathology in measurement of corneal and bulbar conjunctival tumors depth |
Abstract Nr. | 2083 |
Purpose | To compare tumor depth measured by histopathology(HP) with measurements by Ultrasound Biomicroscopy (UBM) and Anterior Segment Optical Coherence Tomography (A-OCT),to investigate whether these techniques are as accurate as HP. |
Methods | 35 patients with 42 corneal or conjunctival bulbar tumors were imaged with A-OCT and UBM in order to measure tumor depth.11 of the tumors were excised and analyzed on histopathology. The correlation of the depth measurement on HP versus A-OCT and UBM was statistically analyzed.When the tumor was not excised, depth measurements on A-OCT versus UBM were compared. |
Results | Statistical analysis showed that UBM and HP measurements of tumor depth are positively correlated,as are UBM and A-OCT measurements.It was not possible to obtain statistically significant data for the correlation between HP and A-OCT measurements because of the small study population.Image quality was overall beter with A-OCT than with UBM,but in 12 tumors,tumor depth measurement on A-OCT was impossible because of posterior tumor back shadowing. |
Conclusion | UBM can measure tumor depth as accurately as HP.Tumor depth measurements on A-OCT and UBM are positively correlated.No relation was found between HP and A-OCT measurements because of the small study population.A larger study is needed to investigate whether measurement of tumor depth with A-OCT is as accurate as HP.Because of the drawbacks of conjunctival tumor depth measurements on histopathology,we think that it is possible that A-OCT and UBM could become the golden standard for measuring corneal and bulbar conjunctival tumor depth.We would use A-OCT if the tumor is not too thick or pigmented and UBM in case of posterior tumor back shadowing. |
Conflict of interest | No |
Last name | LAUWERS |
Initials | N |
Department | UZA |
City | Edegem |
Last name | MERTENS |
Initials | M |
Department | UZA |
City | Edegem |
Last name | JANSSENS |
Initials | K |
Department | UZA |
City | Edegem |
Last name | MATHYSEN |
Initials | D |
Department | UZA |
City | Edegem |
Last name | DE KEIZER |
Initials | RJW |
Department | UZA |
City | Edegem |
Last name | DE GROOT |
Initials | V |
Department | UZA |
City | Edegem |