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Title	Optical Coherence Tomograpy in Cerebral Amyloidosis
Abstract Nr.	1054

Purpose	To compare structural and vascular OCT parameters between cognitive intact (Control) and mild cognitive impairment patients (MCI) with (Aβ+) or without (Aβ-) cerebral amyloid deposition.
Methods	Retinal nerve fiber layer thickness (RNFL), ganglion cell complex (GCC) and parafoveal vessel density were measured using (angio-)OCT in Controls and MCI patients. Differences between subgroups were assessed by t-test. Diagnostic performance in determining amyloid status was evaluated using receiver operating characteristic (ROC) analysis.
Results	35 Controls (16 Aβ+, 19 Aβ-) and 28 MCI patients (8 Aβ+, 20 Aβ-) were included. In the Aβ+ MCI group, RNFL and GCC showed a significant attenuation compared to the Aβ+ Control group (p=0.027 and p=0.006 respectively). Interestingly, a similar decrease was not observed between the Aβ- groups (p>0.05). Within the MCI group, inferior RNFL was significantly thinner in the Aβ+ group compared to the Aβ- group (p=0.005), with an area under the ROC curve for predicting amyloid status of 0.79 (p=0.018). No differences were observed in parafoveal vessel density between subgroups (P>0.05).
Conclusion	This is the first study to investigate retinal OCT parameters in MCI taking cerebral amyloid status into account. In our study the attenuation in RNFL and GCC in MCI appears to be confined to Aβ+ patients. These findings provide further support for the role of OCT in the diagnosis of Alzheimer’s Disease
Conflict of interest	No

Authors 1

Last name	VAN KEER
Initials	K
Department	Dept. of Ophthalmology UZ Leuven
City	Leuven

Authors 2

Last name	Evenepoel
Initials	C
Department	Alzheimer Research Centre KU Leuven
City	Leuven

Authors 3

Last name	Schaeverbeke
Initials	J
Department	Alzheimer Research Centre KU Leuven
City	Leuven

Authors 4

Last name	Abegão Pinto
Initials	L
Department	Department of Ophthalmology Lisboa Norte
City	Lisbon

Authors 5

Last name	Stalmans
Initials	I
Department	Dept. of Ophthalmology UZ Leuven
City	Leuven

Authors 6

Last name	Vandenberghe
Initials	R
Department	Alzheimer Research Centre KU Leuven
City	Leuven

Authors 7

Last name	Vandewalle
Initials	E
Department	Dept. of Ophthalmology UZ Leuven
City	Leuven