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Title	Ciliochoroidal Effusion Syndrome caused by sulpha derivatives: hypothesis for pathophysiologic mechanism
Abstract Nr.	1054

Purpose	Proposal for a pathophysiologic mechanism for a Ciliochoroidal Effusion Syndrome caused by sulpha derivatives
Methods	Review of literature
Results	We propose that an inflow of fluid into the ciliary body exceeds the transport capacity of fluid over the non-pigmented ciliary body epithelium, due to blockage of aquaporin assisted outflow of fluid out of the ciliary body into the posterior chamber. This disequilibrium leads to ciliary body edema leaking into the supra-ciliochoroidal space, pushing the vitreous forward. This pressure leads to anterior displacement of the lens-iris diaphragm with resulting anterior chamber shallowing, myopisation and appositional angle closure.
Conclusion	Our proposal for a pathophysiologic mechanism for a Ciliochoroidal Effusion Syndrome caused by sulpha derivatives gives an explanation for observations found in this syndrome: fluid in the supra-ciliochoroidal space, anterior chamber shallowing, myopisation and appositional angle closure.

Authors 1

Last name	LAMBRECHT
Initials	PL
Department	Ghent University Hospital
City	Gent

Authors 2

Last name	Augustinus
Initials	BA
Department	ZNA Middelheim
City	Antwerpen