Title | 24h IOP control by subchronic AMA0076 in Dutch Belted Rabbits |
Abstract Nr. | P121 |
Purpose | To investigate IOP lowering efficacy of rho kinase (ROCK) inhibitors after subchronic treatment. |
Methods | DBR (5 rabbits/concentration) were treated daily with a single topical dose of AMA0076 or Y-39983 in a masked fashion for 14 days. Saline was used as control in the contralateral eye. IOP was measured before, 3 and 7 hours after treatment. AMA0076 is a locally acting ROCK inhibitor, developed by Amakem Ophthalmics, to reduce side effects such as hyperemia. |
Results | Mean baseline IOP before start of experiment was 21.0 ± 0.4 and 20.7 ± 0.4 mmHg for AMA0076 and Y-39983, respectively. Significant IOP reduction was observed in all treatment groups. A maximal IOP reduction of 39 and 35% was reached with AMA0076 0.1% and Y-39983 0.05%, respectively. Initially, IOP returned to baseline values 24h after administration of AMA0076. After 3 days of treatment with AMA0076 a sustained IOP lowering effect was present: IOP did not return to baseline values, but remained significantly lower for all concentrations of AMA0076. Treatment with Y-39983 did not show this sustained IOP decrease. As a result of this sustained IOP lowering effect smaller IOP fluctuations were observed in animals treated with AMA0076 compared to Y-39983. Hyperemia was observed with all concentrations of Y-39983 whereas only mild hyperemia was induced after administration of AMA0076 0.4. |
Conclusion | Treatment of rabbits with AMA0076 resulted in IOP reduction that was more sustained and associated with smaller peak-through fluctuations than Y-39983. |
Last name | VAN DE VELDE |
Initials | S |
Department | KUL Ophthalmo |
City | leuven |
Last name | Van Bergen |
Initials | T |
Department | KUL Ophthalmo |
City | Leuven |
Last name | Hollanders |
Initials | K |
Department | KUL Ophthalmo |
City | Leuven |
Last name | Sijnave |
Initials | D |
Department | KUL Ophthalmo |
City | Leuven |
Last name | Vandewalle |
Initials | E |
Department | KUL Ophthalmo |
City | Leuven |
Last name | Castermans |
Initials | K |
Department | Amakem Ophthalmics |
City | Diepenbeek |
Last name | Kindt |
Initials | N |
Department | Amakem Ophthalmics |
City | Diepenbeek |
Last name | Moons |
Initials | L |
Department | KUL Biologie |
City | Leuven |
Last name | Leysen |
Department | Amakem Ophthalmics |
City | Diepenbeek |
Last name | Stalmans |
Initials | I |
Department | KUL Ophthalmo |
City | Leuven |