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Type presentatieE-poster
TitelVisual Snow Syndrome and Hallucinogen Persisting Perception Disorder: Clinical Characteristics, Diagnostic Challenges and Therapeutic Approaches in a Cohort
DoelVisual snow syndrome (VSS) and Hallucinogen Persisting Perception Disorder (HPPD) are neuro-ophthalmological disorders causing persistent visual disturbances that impair quality of life. This study reviews their clinical presentation, diagnostic workup, and therapeutic options in a patient cohort.
MethodesPatients presenting with bilateral continuous visual disturbances resembling visual static were retrospectively evaluated. Patients underwent neuro-ophthalmological assessment including OCT, visual field testing, neuroimaging, and electrophysiological investigations.
ResultatenOut of 16 patients (10 males) aged 25–54 years, 11 patients fulfilled diagnostic criteria for VSS and 5 for HPPD. Common symptoms included palinopsia (81% in VSS; 80% in HPPD), headaches (63%; 60%), and photophobia (27%; 60%). All HPPD patients reported prior exposure to substances including cannabis, ecstasy, and cocaine. Three VSS and three HPPD patients reported symptomatic improvement with FL-41 tinted lenses. A reduced frequency and intensity of symptoms were reported by four VSS patients and one HPPD patient treated with lamotrigine. One patient with HPPD reported complete remission after treatment with sertraline. Psychosocial care was proposed to all patients.
ConclusieVSS and HPPD require careful differentiation from ophthalmological and neurological mimics. Despite overlapping characteristics, their distinct triggers and pathophysiological mechanisms should guide management. Prospective studies are needed to establish standardized diagnostic criteria and effective targeted treatments.
BelangenverstrengelingNee
Auteurs 1
NaamNEMR
InitialenA
InstituutDepartment of Ophthalmology, Cliniques Universitaires Saint-Luc
StadBrussels
Auteurs 2
NaamBOYER
InitialenC
InstituutDepartment of Ophthalmology, Cliniques Universitaires Saint-Luc
StadBrussels
Auteurs 3
NaamCOUTEL
InitialenM
InstituutDepartment of Ophthalmology, Cliniques Universitaires Saint-Luc
StadBrussels
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