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TitreClinical impact of 18F-FDG PET CT in the work up of children with uveitis.
ButTo evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) in the work up of paediatric uveitis.
MéthodesWe performed a retrospective study of 12 children followed for uveitis who underwent whole body 18F-FDG PET/ultra low dose CT between 2011 and 2019.
RésultatsThe average patients’ age was 11 years. 100% of patients presented bilateral uveitis, 50% panuveitis and 92% (11/12) had choroidal involvement. 5 of the 12 (42%) patients showed abnormal 18F-FDG uptake on their 18F-FDG PET/CT, including 3 with pathognomonic images of active granulomatous diseases. A biopsy was performed in one of these patients (consistent with sarcoidosis) and in the two others with abnormal 18F-FDG uptake without pathognomonic images of granulomatous disease (one consistent with sarcoidosis, the other negative). Final uveitis diagnosis were idiopathic in 58% of the patients, ocular sarcoidosis in 17% (2/12), TINU in 16,6% (2/12) and tubercular uveitis in 8,3% (1/12).
ConclusionIn this small series, 18F-FDG PET/CT provided important information for uveitis diagnosis in approximatively 30 % (4/12) of our patients. Further studies are needed to define the exact place of 18F-FDG PET/CT and chest CT in the work-up of paediatric uveitis.
Conflit d'intérêtNon
Auteur 1
NomEL MOUDEN
InitialesJ
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
Auteur 2
NomBazewicz
InitialesM
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
Auteur 3
NomMakhoul
InitialesD
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
Auteur 4
NomGoffin
InitialesL
InstitutPediatric Immuno-Rheumatology - CHU HUDERF - ULB
VilleBruxelles
Auteur 5
NomJudice
InitialesL
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
Auteur 6
NomCaspers
InitialesL
InstitutOphthalmology - CHU St-Pierre - ULB
VilleBruxelles
Auteur 7
NomDraganova
InitialesD
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
Auteur 8
NomGarcia
InitialesC
InstitutNuclear Medicine - CHU St-Pierre - ULB
VilleBruxelles
Auteur 9
NomWillermain
InitialesF
InstitutOphthalmology - CHU St-Pierre and CHU Brugmann - ULB
VilleBruxelles
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