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TitreOutcome after Intracameral Dexamethasone Injection Due to Endothelial Immune Reaction after Keratoplasty
ButTo evaluate the effectiveness of intracameral dexamethasone injection (IDI) after endothelial immune reaction (EIR) and the role of the laser flare meter (LFM) for diagnostic and follow-up.
MéthodesThis study included 50 eyes presenting with an EIR after penetrating keratoplasty (PKP) (n = 46) or DMEK (n = 4). All patients received an IDI (400µg dexamethasone). We analyses the best corrected visual acuity (BCVA), the central corneal thickness (CCT) and corneal volume (CV) and the anterior chamber flare (ACF) preoperatively, 6 weeks and 6 months following the IDI.
RésultatsThe BCVA increased from LogMar 1.03 +/- 0.62 to 0.7 +/- 0.56 (p < 0.001) and 0.84 +/- 0.65 (p = 0.03) at 6 weeks and 6 months after IDI. For the same periods of measures, the CCT decreased from 833 +/- 384 µm to 661 +/- 169 (p < 0.001) and 601 +/- 89 µm (p < 0.001). The CV decreased from 79 +/- 12 mm^3 to 71 +/- 12 (p < 0.001) and 70 +/- 12 mm^3 (p = 0.01). The ACF varied from 23 +/- 22 phot/ms to 25 +/- 24 (p = 0.96) at 6 weeks after IDI.
ConclusionThe ICI seems to be an effective and secure adjuvant approach for treatment of EIR after PKP or DMEK. ACF is probably not an accurate method to evaluate the EIR, presumably due to the poor quality of the measurements through the decompensated cornea and corneal opacities.
Conflit d'intérêtNon
Auteur 1
NomHAMON
InitialesL
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 2
NomDAAS
InitialesL
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 3
NomMILIOTI
InitialesG
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 4
NomLAURIK
InitialesKL
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 5
NomHARTMANN
InitialesM
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 6
NomXANTHOPOULOU
InitialesK
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
Auteur 7
NomSEITZ
InitialesB
InstitutSaarland University Medical Center (UKS)
VilleHomburg/Saar, Germany
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