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TitreCancer-associated rethinopathy secondary to gallbladder carcinoma
ButPresenting a case report of a patient with cancer-associated retinopathy (CAR) secondary to a gallbladder carcinoma.
MéthodesThe diagnosis of CAR was suspected on grounds of anamnesis, clinical features and technical investigations (VF, OCT, FF-ERG, PET-CT, immunofluorescence antibody screening). Initial treatment consisted of high dose corticosteroids (1mg/kg/day)
RésultatsA positive clinical evolution was found after treatment with high-dose corticoids with disappearance of uveitis symptoms and gradual improvement of visual acuity and VF.
ConclusionCAR is a rare disease entity caused by auto-antibodies against retinal antigens. The disease is associated with a wide spectrum of malignancies. Clinical features are progressive VF narrowing, diminished visual acuity, macular edema, vitritis, fundus changes, photophobia, diminished color perception. Cortisone therapy with or without plasmapheresis can be considered as a first choice treatment. Corticoid saving immunosuppressive therapy and/or biologicals can be used as maintenance therapy. The long term prognosis is uncertain because further evolution is possible.
Conflit d'intérêtNon
Auteur 1
NomGOYVAERTS
InitialesK
InstitutUniversiteit Antwerpen
VilleWilrijk
Auteur 2
NomVAN LINT
InitialesM
InstitutUniversitair Ziekenhuis Antwerpen
VilleEdegem
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