Titre | Quantification of changes in foveal capillary architecture induced by idiopathic epiretinal membrane using OCT-Angiography |
Abstract Nr. | 2073 |
But | To quantify the extent and depth of distortion of the foveal capillary architecture due to traction of idiopathic epiretinal membrane (ERM) using optical coherence tomography angiography (OCT-A). |
Méthodes | Multimodal imaging including OCT-A (Angiovue, Optovue) was performed in 42 eyes with idiopathic ERM (72.4 years +/-6.8). Based on 6x6mm2 OCT-A images, a macular vessel density ratio (MVR=VDfo [Vessel density foveal region]/VDp [vessel density parafoveal region]) was calculated for the superficial (s), deep (d) and full-thickness (f) slabs to assess a depth-resolved, non-invasive evaluation of foveal distortion. The acquired data were subdivided in a patient group with mild and severe BCVA reduction due to ERM. Data was compared to age-matched healthy controls. |
Résultats | In all three slabs, MVR was significantly smaller in the control group in comparison with the ERM group: MVRs: 0.63 +/- 0,1 vs 0.83 +/- 0.1 (p>0.001); MVRd: 0.60 +/- 0.1 vs 0.73 +/- 0.1 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.82 +/- 0.1 (p<0.001). Group 1 (BCVA <0.4 LogMar) showed a significantly higher MVR in comparison with the control group in the superf. plexus only: MVRs: 0.64 +/- 0.1 vs 0.78 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.65 +/- 0.2 (p=0.3); MVRf: 0.68 +/- 0.1 vs 0.77 +/- 0.1 (p=0.01). However, group 2 (BCVA >= 0.4 LogMar) showed a significantly higher MVR in all three slabs: MVRs: 0.64 +/- 0.1 vs 0.86 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.77 +/- 0.2 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.85 +/- 0.1 (p<0.001). |
Conclusion | Assessing MVR using OCT-A may serve as a tool to quantify the extent and depth of distortion of the foveal capillary architecture due to traction of ERM. |
Conflit d'intérêt | Non |
Nom | NELIS |
Initiales | P |
Institut | UKM, UZB |
Ville | Muenster, Brussels |
Nom | Alten |
Initiales | F |
Institut | UKM |
Ville | Muenster |
Nom | Clemens |
Initiales | C |
Institut | UKM |
Ville | Muenster |
Nom | Heiduschka |
Initiales | P |
Institut | UKM |
Ville | Muenster |
Nom | Van Lint |
Initiales | M |
Institut | UZB |
Ville | Brussels |
Nom | Ten Tusscher |
Initiales | M |
Institut | UZB |
Ville | Brussels |
Nom | Eter |
Initiales | N |
Institut | UKM |
Ville | Muenster |