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Cet abstract a été assigné à session AOB Poster session 1 - Glaucoma – Posterior segment/Retinal disease
TitreBlepharoptosis and external ophthalmoplegia associated with long-term antiretroviral therapy in human immunodeficiency virus-infected patients
Abstract Nr.1031
ButTo present two cases of patients infected with human immunodeficiency virus (HIV) who developed a clinical picture of chronic progressive external ophthalmoplegia (CPEO) after long-term antiretroviral therapy.
MéthodesIn these 2 adult patients presenting with a clinical picture of CPEO, a biological and radiological work-up was performed to disclose myasthenia or classic CPEO of mitonchondrial origin. These patients share in common more than 10 years of antiretroviral therapy for HIV.
RésultatsThe biological and radiological work up could not elicit myasthenia nor classic CPEO as the cause of our patient’s clinical picture. Acetylcholine receptor antibody and lactate titers were not increased. Orbital MRI was rather unremarkable.
ConclusionWe conclude that our patients have a CPEO-like syndrome relied to HIV disease and antiretroviral therapy, as already described in the literature. Antiretroviral therapy includes nucleoside reverse-transcriptase inhibitors and protease inhibitors, both of which are known causes of skeletal myopathy. Nucleoside reverse-transcriptase inhibitors interfers with mitochondrial DNA polymerase gamma. Mutations in the same enzyme have been demonstrated in patients with CPEO. Mitochondrial dysfunction might be the common link between these 2 similar pictures of different origins.
Conflit d'intérêtNon
Auteur 1
NomBOUAICH
InitialesK
InstitutHôpital universitaire Erasme
VilleBruxelles
Auteur 2
NomRemiche
InitialesG
InstitutHôpital universitaire Erasme
VilleBruxelles
Auteur 3
NomGoffard
InitialesJC
InstitutHôpital universitaire Erasme
VilleBruxelles
Auteur 4
NomDavid
InitialesP
InstitutHôpital universitaire Erasme
VilleBruxelles
Auteur 5
NomVan Nechel
InitialesC
InstitutHôpital universitaire Erasme
VilleBruxelles
Auteur 6
NomCordonnier
InitialesM
InstitutHôpital universitaire Erasme
VilleBruxelles
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