Title | A vascular comparison between primary open-angle glaucoma and normal-tension glaucoma |
Abstract Nr. | 1020 |
Purpose | To contrast systemic and ocular cardiovascular parameters in patients with normal-tension glaucoma (NTG) versus primary open-angle glaucoma (POAG). |
Methods | Cross-sectional study investigating ocular blood flow in glaucoma patients. Systemic and ocular cardiovascular parameters, including a questionnaire, blood pressure, dynamic contour tonometry, colour Doppler imaging, retinal oximetry and OCT, were compared between a matched group of POAG and NTG patients. |
Results | 192 NTG and 214 POAG patients were included in the analysis. Patients with NTG presented with significantly lower diastolic blood pressure (P=0.01), decreased acceleration in the central retinal artery (P=0.02), increased resistive index in the ophthalmic artery and central retinal vein (both P=0.04), thinner peripapillary choroidal thickness (P<0.001) and higher retinal venous oxygen saturation (P<0.001). The odds of suffering from hypotension, migraine and Raynaud were significantly higher for NTG patients (95% confidence interval (CI) 1.30-8.73, 1.13-4.42 and 1.36-3.95 respectively), as were the odds of taking systemic bèta-blockers, calcium antagonists and angiotensin II receptors blockers (95% CI 1.04-2.67, 1.21-6.62 and 1.18-5.97 respectively). |
Conclusion | Patients with NTG differ significantly on several ocular and systemic cardiovascular parameters form POAG patients. These findings add further support to a vascular etiology in NTG. |
Conflict of interest | No |
Last name | VAN KEER |
Initials | K |
Department | Department of Ophthalmology, UZ Leuven |
City | Leuven |
Last name | Abegão Pinto |
Initials | L |
Department | Department of Ophthalmology, Centro Hospitalar Lisboa Norte |
City | Lisbon |
Last name | Barbosa Breda |
Initials | J |
Department | Department of Ophthalmology, Centro Hospitalar São João |
City | Porto |
Last name | Willekens |
Initials | K |
Department | Department of Ophthalmology, UZ Leuven |
City | Leuven |
Last name | Stalmans |
Initials | I |
Department | Department of Ophthalmology, UZ Leuven |
City | Leuven |
Last name | Vandewalle |
Initials | E |
Department | Department of Ophthalmology, UZ Leuven |
City | Leuven |