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Cet abstract a été assigné à session FRO: Fund for Research in Ophthalmology
TitreFRO: Rho Kinase Inhibitor AMA0526 Improves Surgical Outcome in a Rabbit Model of Glaucoma Filtration Surgery
Abstract Nr.1032
ButTo elucidate the effect of a locally acting, selective ROCK inhibitor on the wound healing process and surgical outcome of glaucoma filtration surgery.
MéthodesThe in vivo effect of topical AMA0526 0.3% TID was investigated in a rabbit model of glaucoma filtration surgery. Treatment outcome was studied by clinical investigation of the bleb area as well as immunohistological analyses for inflammation, angiogenesis and collagen deposition at day 8, 14 and 30 after surgery. Vehicle was used as control in seperate groups.
RésultatsAMA0526 significantly improved bleb area and survival compared to vehicle treated eyes. Immunohistological analyses showed significant reduction of inflammation, angiogenesis and collagen deposition after treatment with the ROCK inhibitor. Compared to vehicle, inflammation was decreased by 33% at 8 days, angiogenesis was reduced by 52% on day 8 and by 29% at 14 days, and collagen deposition by 30% on surgical day 30.
ConclusionThis study shows that AMA0526 is able to improve glaucoma surgery outcome in rabbits. In addition to improved bleb area, AMA0526 led to decreased inflammation, angiogenesis and fibrosis. This study can open new perspectives for a safer and more efficient glaucoma surgery.
Auteur 1
NomVAN DE VELDE
InitialesS
InstitutKUL
VilleLeuven
Auteur 2
NomVan Bergen
InitialesT
InstitutKUL
VilleLeuven
Auteur 3
NomVandewalle
InitialesE
InstitutKUL/UZ
VilleLeuven
Auteur 4
NomCastermans
InitialesK
InstitutAmakem
VilleDiepenbeek
Auteur 5
NomKindt
InitialesN
InstitutAmakem
VilleDiepenbeek
Auteur 6
NomMoons
InitialesL
InstitutKUL
VilleLeuven
Auteur 7
NomStalmans
InitialesI
InstitutKUL/UZ
VilleLeuven
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