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TitreLow grade T cell primary CNS lymphoma with secondary choroïdal and orbital extension: a case report
Abstract Nr.P018
ButA 49-year old female was referred to the Eye Hospital with sudden loss of left visual acuity.
She had a 8-year old history of suspected low grade T cell primary CNS lymphoma, though pathology report of the left IVth ventricle roof biopsy at the time did not exclude a granulomatous pseudotumor. Clinical course had been atypical as cerebral lesions had regressed spontaneously and patient had therefore rejected any radio-or chemiotherapeutic proposal so far.
Clinical and ultrasonic examination of the left eye showed a non-pigmented choroïdal mass with secondary retinal detachment and orbital extension.
Microscopic examination of the orbital biopsy revealed diffuse non-necrotic granulomatous infiltrates with foci of T-lymphocytic aggregation. Only their microdissection and PCR permitted to detect TCR y and TCR y-CDR3 gene rearrangement, finally confirming the exceptional diagnosis of low grade T cell primary CNS lymphoma with secondary choroïdal and orbital extension.
Author 1
NomSCHALENBOURG
InitialesA
VilleLausanne
Author 2
NomGuex-Crosier
InitialesY
VilleLausanne
Author 3
NomChan
InitialesC
VilleLausanne
Author 4
NomZografos
InitialesL
VilleLausanne
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