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TitreIntracameral bevacizumab as an adjunct to trabeculectomy: a one year prospective, randomized study.
Abstract Nr.1045
ButTo investigate the efficacy and safety of a single intracameral bevacizumab injection to improve the outcome of trabeculectomy.
MéthodesA 12-month, prospective, randomized, double-masked, placebo-controlled trial. Patients with medically uncontrolled open-angle glaucoma scheduled for a primary trabeculectomy were recruited and randomized to receive 50 µl of either bevacizumab (1.25 mg) or placebo (balanced salt solution) peroperatively. Absolute success was defined as intraocular pressure (IOP) ≤ 18 mmHg and > 5 mmHg with at least 30% reduction from baseline and no loss of light perception. Success through the use of additional medical and/or surgical IOP-lowering treatments was defined as qualified success.
Résultats138 patients completed a 12-month follow-up, 69 of whom in the bevacizumab treated group. IOP at 1 year postoperatively was significantly lower than baseline (placebo: 25.6±9.9mmHg vs. 11.5±3.9mmHg, p<0.01; bevacizumab: 24.8±8.1mmHg vs. 11.9±3.8mmHg, p<0.01), with no difference between treatment groups (p=0.69). However, absolute success was higher in the bevacizumab group (71% vs. 51%, p=0.02), with the need for IOP-lowering interventions (needlings) being lower in this group (13% vs. 36%, p=0.003). Complication rates were low and comparable between groups.
ConclusionPeroperative administration of intracameral bevacizumab significantly reduces the need for additional interventions during the follow-up of patients undergoing trabeculectomy.
Auteur 1
NomVANDEWALLE
InitialesE
InstitutUZLeuven
VilleLeuven
Auteur 2
NomAbegao Pinto
InitialesL
InstitutCentro Hospitalar Lisboa Central
VilleLisbon
Auteur 3
NomVan Bergen
InitialesT
InstitutKULeuven
VilleLeuven
Auteur 4
NomMoons
InitialesL
InstitutKULeuven
VilleLeuven
Auteur 5
NomSpileers
InitialesW
InstitutUZLeuven
VilleLeuven
Auteur 6
NomZeyen
InitialesT
InstitutUZLeuven
VilleLeuven
Auteur 7
NomStalmans
InitialesI
InstitutUZLeuven
VilleLeuven
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