THE BELGIAN OPHTHALMIC ASSOCIATIONS
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Cet abstract a été assigné à session BGS: Belgian Glaucoma Society
| Titre | The effect of a single, preoperative, intracameral administration of bevacizumab (Avastin®) on trabeculectomy outcome: A prospective, randomized, double-blinded, placebo-controlled trial. |
| But | To investigate the effect of a single, preoperative administration of bevacizumab (Avastin®) in terms of clinical outcome following trabeculectomy in patients with either primary open-angle glaucoma (POAG) or normal tension glaucoma (NTG). |
| Méthodes | 141 medically uncontrolled glaucoma patients who were scheduled for primary trabeculectomy were included in this prospective, randomized, double-blinded and placebo-controlled study. Patients were divided into POAG and NTG, which were then randomized to receive 50 µl of either bevacizumab (25 mg/ml) or placebo peroperatively. NTG patients also received mitomycin C. The target intraocular pressure (IOP) range was between 6 and 18 mmHg for POAG and between 6 and 14 mmHg for NTG. Absolute success was defined as meeting the target IOP at 6 month of follow-up without IOP-lowering medications or postoperative interventions. Qualified success was defined as meeting the target IOP at month 6 with or without either IOP-lowering medications and/or postoperative surgical interventions. |
| Résultats | Absolute success in the bevacizumab group was 83% compared to 59% in the placebo group (p=0.003, Odds Ratio (OR) 3.3, confidence interval (CI) 1.4-7.9). Qualified success was 99% in the bevacizumab group versus 94% in the placebo group (not significant, OR 4, CI 0.3-201). Needlings were significantly less frequent in the bevacizumab group as compared to the placebo group, respectively in 11% versus 32% (p=0.004). Complication rates were comparable in both groups. |
| Conclusion | A single preoperative intracameral administration of bevacizumab was associated with increased absolute success rates and reduced need for postoperative interventions. |
Auteur 1
| Nom | VANDEWALLE |
| Initiales | E |
| Institut | UZLeuven |
| Ville | Leuven |
Auteur 2
| Nom | ZEYEN |
| Initiales | T |
| Institut | UZLeuven |
| Ville | Leuven |
Auteur 3
| Nom | VAN BERGEN |
| Initiales | T |
| Institut | UZLeuven |
| Ville | Leuven |
Auteur 4
| Nom | SPIELBERG |
| Initiales | L |
| Institut | Rotterdam Eye Hospital |
| Ville | Rotterdam |
Auteur 5
| Nom | STALMANS |
| Initiales | I |
| Institut | UZLeuven |
| Ville | Leuven |