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Titre

Frequency of metastatic disease and survival of 716 consecutive patients with uveal melanoma : a retrospective monocentric reviewmelanoma

But	To determine the frequency, location, time to systemic metastases and survival in patients with uveal melanoma managed at one cancer center
Méthodes	A retrospective review on 716 consecutive patients, referred and managed at the Centre du Cancer, Brussels for uveal melanoma between 1/1998 and 12/2010. Patient survival was assessed by Kaplan-Meier method and the impact of metastatic diesase–related symptoms on survival by the Log-Rank test. A multivariate Cox regression was performed to identify risk factors for metastatic disease.
Résultats	The median age at diagnosis was 63 years. According to the COMS classification, there were 43 (6%) small tumors, 379 (53%) medium tumors, 232 (32%) large tumors and 62 (9%) tumors were unclassified. Enucleation, radiotherapy+/-thermotherapy and thermotherapy alone was performed in 24%, 66% and 10% of patients, respectively. The median time between tumor diagnosis and treatment was 9 days. After a median follow-up of 36 months 100 patients (13.9%) developed metastases (71% exclusively liver localisation, 19% extraliver and liver localisations and 5% only extraliver localisation) with a median time to relapse of 32 months. The relapse free survival from diagnosis at 5 and 10 years was 81% and 74,6%, respectively. Fourty patients (40%) died from their melanoma with a median survival time of 17 months. No difference in survival was observed between those patients with metastasis-related symptoms and those without (p> 0.05).
Conclusion	Our study showed a lower frequency (14%) of metastatic disease with a higher median survival time than those previously reported. The potential impact of the treatment(s) on survival prognosis among our patients with metastatic disease is under investigation

Auteur 1

Nom	DE POTTER
Initiales	P
Institut	Cliniques Universitaires St-Luc
Ville	Bruxelles

Auteur 2

Nom	Hammouch
Initiales	F

Auteur 3

Nom	Francart
Initiales	D

Auteur 4

Nom	Baurain
Initiales	JF