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Type presentatie	E-poster
Titel	For ROP treatment, a 4 mm, 32G TSK needle, might be a more guarded option for administration of aflibercept with a picleo pediatric dosing device

Doel	Intravitreal injections of anti-VEGF are used as an alternative or adjuvant to laser photocoagulation in the treatment of retinopathy of prematurity (ROP). Accurate dosing of anti-VEGF is necessary but difficult in preterm infant eyes. A Picleo pediatric dosing device (PPDD) can be used to accurately administer 10µL of aflibercept and is intended to be used with a 30G, 13mm needle. A thinner and shorter 32G, 4mm (TSK) needle could possibly be used to reduce the risk of potentially puncturing the retina. The aim of this study is to establish if there is a difference in administered volume between a 30G and a 32G needle when used with a PPDD
Methodes	In this in-vitro bench-test one PPDD was used to measure the volume of demineralized water delivered via either a 32G needle or the intended 30G needle. In total 16 repetitions (8 per configuration) were performed. The volume was determined gravimetrically by converting the weight to volume using the temperature-corrected density of demineralized water
Resultaten	The mean delivered volume was 12.28µL with a 32G, 4mm needle and 12.36µL with the standard 30G, 13mm needle; a non-significant difference of 0.08 µL (95% CI, −0.21 to +0.36 µL, <4% of nominal). All repetitions delivered more than the 10µL nominal target, all repetitions fell within the intended range of 8µL-14µL
Conclusie	The use of a 4mm needle in combination with the PPDD to administer 10µL of aflibercept did not result in a statistically significant difference in administered volume compared to the 13mm needle. This suggests that a 4mm, 32G needle can be used without compromising dosing accuracy, which might be a more guarded option for administration of aflibercept in the pediatric eye
Belangenverstrengeling	Ja
Details verstrengelde belangen	PPDD device test by SJJ solutions

Auteurs 1

Naam	VAN ZEEBURG
Initialen	E
Instituut	UZA, UA
Stad	Antwerp

Auteurs 2

Naam	van Hal
Initialen	B
Instituut	SJJ solutions
Stad	The Hague

Auteurs 3

Naam	Aelbrecht
Initialen	G
Instituut	UZA
Stad	Antwerp