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Type presentatieOral presentation
TitelVisual, Refractive and Tomographic Outcomes After Mitomycin-Free Manual Superficial Keratectomy for Salzmann Nodular Degeneration and Peripheral Hypertrophic Subepithelial Corneal Degeneration: A Retrospective Cohort Study
DoelTo evaluate visual, refractive, keratometric, aberrometric and densitometric outcomes after manual superficial keratectomy (MSK) without adjuvant mitomycin C (MMC) for Salzmann nodular degeneration (SND) and peripheral hypertrophic subepithelial corneal degeneration (PHSCD).
MethodesRetrospective cohort study of patients treated with MSK without adjuvant MMC at Ghent University Hospital. Outcomes included best-corrected visual acuity (BCVA), refraction and Scheimpflug-based tomography, aberrometry and densitometry (Pentacam). Recurrence rate and complications were recorded.
ResultatenPre- and postoperative outcomes were compared in 56 eyes of 38 patients (50 SND, 6 PHSCD) over a median follow-up of 4.6 (mean 13.8) months. BCVA improved from 0.20 to 0.08 logMAR, spherical equivalent from +1.51 to −0.85D, refractive cylinder from −4.56 to −1.24D and corneal astigmatism from 4.31 to 1.40D (all P < 0.001). K1 increased from 38.92 to 42.26 D (P < 0.001), with a smaller increase in K2 (43.25 to 43.67D; P = 0.009). Higher-order root-mean-square aberrations decreased from 2.79 to 1.12µm (P < 0.001) and total root-mean-square aberrations from 7.30 to 3.27µm (P < 0.001). Corneal densitometry did not change significantly in any prespecified zone. Nodular recurrence occurred in one eye (1.8%); secondary pterygia developed in 4 eyes (7.1%); no intraoperative complications occurred.
ConclusieIn this retrospective cohort of eyes with SND or PHSCD, MSK without adjuvant MMC was associated with significant visual, refractive, keratometric and aberrometric improvement. We consider this approach an effective first-line surgical option in symptomatic or visually significant SND and PHSCD.
BelangenverstrengelingNee
Auteurs 1
NaamHOUBEN
InitialenI
InstituutUZ Gent
StadGent
Auteurs 2
NaamMourisse
InitialenS
InstituutUZ Gent
StadGent
Auteurs 3
NaamDerveaux
InitialenT
InstituutUZ Gent
StadGent
Auteurs 4
Naamvan Gremberghe
InitialenI
InstituutUZ Gent
StadGent
Auteurs 5
NaamKreps
InitialenE
InstituutUZ Gent
StadGent
Auteurs 6
NaamRoels
InitialenD
InstituutUZ Gent
StadGent
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