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Type presentatie	Oral presentation
Titel	Therapeutic Drug Monitoring of Adalimumab in Paediatric non-infectious Uveitis: A Retrospective Analysis

Doel	To evaluate the use of therapeutic drug monitoring (TDM) of adalimumab in children with chronic non-infectious uveitis (NIU).
Methodes	Children with chronic NIU diagnosed under the age of 16, treated with adalimumab, with (group 1) or without (group 2) concomitant immunomodulating treatment (IMT), with at least one available serum adalimumab trough level (TL) and anti-adalimumab antibody (AAA) level were included in this retrospective cohort study. Controlled uveitis was defined as an anterior chamber activity ≤0.5 cells on ≤2 steroid eye drops per day.
Resultaten	A total of 37 children (73 eyes) treated with adalimumab for NIU were included (median age, 7.4 years; range, 2.2–13.8). During a median duration of 29 months (range 5-79), 200 TL were measured, with a median concentration of 13.4 µg/ml (range 0–33), and TDM-based therapeutic adjustments were performed in 22 patients (59.5%). In group 1 (n=28), treatment was escalated in 9 patients (32.1%), resulting in increased adalimumab levels (median +4.1 µg/ml, range [-0.7; +15.6]) in 7 patients (87.5%), and regained uveitis control in 5 of 8 patients (62.5%). In group 2 (n=9), 4 patients developed primary treatment failure, with TL <0.5 µg/ml and elevated AAA levels. In 3 of the remaining 5 patients, treatment adjustments (both escalation and taper) were made.
Conclusie	TDM of adalimumab is a promising tool to optimise the clinical outcome and limit treatment related side effects in pediatric uveitis.
Belangenverstrengeling	Nee

Auteurs 1

Naam	PARK
Initialen	C
Instituut	Dpt of Ophthalmology (Ghent UH)
Stad	Ghent

Auteurs 2

Naam	BONROY
Initialen	C
Instituut	Dpt of Clinical Biology (Ghent UH)
Stad	Ghent

Auteurs 3

Naam	DEHOORNE
Initialen	JL
Instituut	Dpt of Pediatric Rheumatology (Ghent UH)
Stad	Ghent

Auteurs 4

Naam	KREPS
Initialen	EO
Instituut	Dpt of Ophthalmology (Ghent UH)
Stad	Ghent