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Type presentatieE-poster
TitelBilateral ocular surface inflammation during dupilumab therapy
DoelTo describe bilateral ocular surface inflammation developing during prolonged dupilumab therapy and its clinical evolution.
MethodesA patient receiving dupilumab presented with two months of progressive bilateral ocular redness and swelling, without pain, discharge or visual loss. Clinical findings, microbiological investigations and response to treatment were documented.
ResultatenInitial examination showed marked tarsal and bulbar hyperemia, pronounced follicular conjunctivitis involving the bulbar conjunctiva, marked limbitis and moderate superficial punctate keratitis. The corneas were clear and the anterior chambers were deep and quiet without cells. Extensive microbiological testing, including bacterial cultures and PCR for adenovirus, Chlamydia trachomatis and Neisseria gonorrhoeae, was negative, as was viral culture. Topical dexamethasone led to marked clinical improvement, with resolution of the bulbar follicular reaction, near-complete resolution of limbitis and only mild conjunctival hyperemia at follow-up. A developing symblepharon and persistent inferior interpalpebral superficial punctate keratitis were noted. Dupilumab had been used for approximately 1–1.5 years and was continued.
ConclusieThe clinical presentation, negative infectious work-up and response to corticosteroids were compatible with dupilumab-associated ocular surface disease. However, causality could not be established as dupilumab was continued. This case highlights the importance of considering a drug-associated inflammatory etiology in bilateral conjunctivitis with a negative infectious work-up.
BelangenverstrengelingNee
Auteurs 1
NaamKEYTSMAN
InitialenE
InstituutUZ Brussel
StadJette
Auteurs 2
NaamSalman
InitialenS A
InstituutUZ Brussel
StadJette
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