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TitreOcular adverse events in atopic dermatitis patients under dupilumab or other systemic immunomodulator treatment: a retrospective study
ButTo assess the frequency, presentation, timing, severity and management of treatment-related ocular adverse events in adults with atopic dermatitis (AD) receiving dupilumab or other systemic immunomodulators.
MéthodesEighty-six adults with AD receiving dupilumab (n=60), lebrikizumab (n=6), tralokinumab (n=8), baricitinib (n=3), abrocitinib (n=5) or cyclosporine (n=62) at UZ Brussel (June 2020-July 2025) were retrospectively reviewed. Multiple patients (n=58) received more than one immunomodulatory therapy in the course of the study. Ocular symptoms, findings, severity, management and documentation source were recorded. For multiple events, only the first treatment-related event was analysed.
RésultatsOf 86 patients, 26 (30.2%) had treatment-related ocular complaints. First events occurred during dupilumab treatment in 23/26 (88.5%) and during treatment with lebrikizumab, tralokinumab and cyclosporine in one each. Median onset was 16.5 weeks. Dry eye/sicca was the most frequent symptom (50.0%) and conjunctivitis the most frequent clinical finding (61.5%). Ocular treatment was prescribed in 21/26 of the patients (80.8%); systemic therapy was modified in 6/26 (23.1%). Documentation of ocular complaints was only by the dermatology department in 14/26 of the cases (53.8%), combined by the dermatology and the ophthalmology department in 11/26 (42.3%) and by ophthalmology-only in 1/26 (3.8%).
ConclusionOcular complaints occurred predominantly during dupilumab treatment and were clinically relevant in the majority of cases. Frequent dermatology documentation and treatment impact support the need for structured screening, timely ophthalmology referral and interdisciplinary management.
Conflit d'intérêtNon
Auteurs 1
NomTALLAL
InitialesS
InstitutVrije Universiteit Brussel
VilleJette
Auteurs 2
NomOellerich
InitialesS
InstitutUZ Brussel
VilleJette
Auteurs 3
NomGutermuth
InitialesJ
InstitutUZ Brussel
VilleJette
Auteurs 4
NomNí Dhubhghaill
InitialesS
InstitutUZ Brussel
VilleJette
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