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Deze abstract is toegekend aan sessie AOB Free Papers 2
Type presentatieOral presentation
TitelEfficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients with Severe Dry Eye Disease: a prospective, blinded, randomized, crossover study
DoelTo evaluate the efficacy and safety of 20% and 100% autologous serum eye drops (ASED), compared to preservative-free artificial tears (PFAT), as a treatment for severe dry eye disease (DED).
MethodesForty-six patients with severe DED were randomized to receive PFAT, ASED 20% and ASED 100% for 8 weeks in a crossover study design. The primary outcome measure was an assessment of ocular symptoms, using the OSDI questionnaire. Secondary outcomes were Schirmer 1 test, BCVA, ocular surface staining (OSS) using the Sjögren's International Collaborative Clinical Alliance (SICCA) OSS score, tBUT, non-invasive tBUT, conjunctival injection score and MGD grading. Additionally, serum and tear cytokine analysis and microbiological cultures were performed.
ResultatenUse of ASED 100% resulted in the most significant improvement in both the OSDI and SICCA OSS scores compared to baseline. Direct comparison with PFAT revealed additional improvements in OSDI and OSS scores after treatment with both ASED 20% and 100%. No significant differences between treatments were found for all other secondary outcomes. Cultures were positive in more than half of the used PFAT and ASED vials, with the majority containing commensal flora. No serious adverse events were observed. Analysis of tear cytokines suggested that ASED promotes a less inflammatory ocular environment than PFAT.
ConclusieTreatment with autologous serum eye drops is safe and yields statistically and clinically significant improvements in both subjective and objective DED parameters. Increasing autologous serum concentration is an effective treatment option for patients with severe dry eye disease.
BelangenverstrengelingNee
Auteurs 1
NaamROELS
InitialenD
InstituutGhent University Hospital
StadGhent
Auteurs 2
NaamLeroy
InitialenBP
InstituutGhent University Hospital
StadGhent
Auteurs 3
NaamClaerhout
InitialenI
InstituutAZ Maria Middelares Hospital
StadGhent
Auteurs 4
NaamKerre
InitialenT
InstituutGhent University Hospital
StadGhent
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