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Type presentatieOral presentation
TitelComparative study of PRESERFLOTM MicroShunt, XEN45® Gel Stent and Trabeculectomy in open-angle glaucoma
DoelTo compare the safety and efficacy of PRESERFLOTM MicroShunt (MS), trabeculectomy (Trab) and XEN45® Gel Stent (XEN) in patients with open-angle glaucoma during the first year.
MethodesA single-centre retrospective case-control study was conducted on all eyes that underwent standalone glaucoma surgery between 2013 and 2020.

The primary outcome was surgical success after 1 year. Complete success was defined as intraocular pressure (IOP) of 6–15 mmHg or 6–18 mmHg, without vision loss, additional glaucoma surgery, or IOP-lowering medication. Qualified success allowed medication and/or laser therapy. Secondary outcomes included visual acuity, medication use, and complications.
ResultatenIn total, 384 eyes of 384 patients were included, 82 eyes received a MS, 117 a Trab and 185 a XEN. MS achieved the highest rates of both complete and qualified success across both IOP criteria. Regarding complete success, MS was equal to Trab (p=0.207, IOP 6-15mmHg and p=0.230, IOP 6-18). MS (p<0,001) and Trab (p=0.030 and p=0.018, respectively) performed significantly better than XEN. For qualified success, MS showed superior outcomes, with statistical significance only observed comparing MS to XEN in the IOP 6-18 mmHg group (p=0.049).
Significant hypotony was rare across groups and peaked in the first week. Minor interventions were more frequent after Trab.
ConclusieMS and Trab achieved comparable success rates and outperformed XEN without use of medication. MS demonstrated superior efficacy over XEN regardless of medication use. MS and Xen need fewer post-operative interventions compared to Trab.
BelangenverstrengelingJa
Details verstrengelde belangenI. S. received a research grant from AbbVie and Santen.
Auteurs 1
InitialenMI
NaamBillen
InstituutUZL/KUL
StadLeuven
Auteurs 2
InitialenT
NaamJacobs
InstituutUZL/KUL
StadLeuven
Auteurs 3
InitialenJ
NaamVan Eijgen
InstituutUZL/KUL
StadLeuven
Auteurs 4
InitialenS
NaamLemmens
InstituutUZL/KUL
StadLeuven
Auteurs 5
InitialenE
NaamVandewalle
InstituutUZL/KUL
StadLeuven
Auteurs 6
InitialenI
NaamStalmans
InstituutUZL/KUL
StadLeuven
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