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Type presentatieE-poster
TitelConjunctival TFG::ROS1 fusion positive inflammatory myofibroblastic tumor treated with crizotinib
DoelTo describe the clinical course and management of a conjunctival inflammatory myofibroblastic tumor with a TFG::ROS1 fusion in a 33-year-old woman presenting with a progressively enlarging subconjunctival mass.
MethodesDiagnosis was confirmed by biopsy and RNA next-generation sequencing.
ResultatenTreatment with the tyrosine kinase inhibitor crizotinib led to complete tumor resolution, however therapy was discontinued due to a sarcoid-like granulomatous reaction. Visual acuity remained stable at 20/20 throughout, and no recurrence was observed.
ConclusieThis case highlights the diagnostic challenges of conjunctival inflammatory myofibroblastic tumor, the therapeutic potential of targeted kinase inhibition, and the critical role of genomic profiling in guiding personalized treatment for rare ocular tumors such as inflammatory myofibroblastic tumor.
BelangenverstrengelingNee
Auteurs 1
InitialenL
NaamBourdeaud'huy
InstituutUniversiteit Gent
StadGent
Auteurs 2
InitialenD
NaamRoels
InstituutUZ Gent
StadGent
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