Abstract bekijken

Deze abstract is toegekend aan sessies
Type presentatieE-poster
TitelThe influence of internuclear ophthalmoplegia on the results of the Symbol Digit Modalities Test in patients with multiple sclerosis.
DoelInternuclear ophthalmoplegia (INO) and cognitive decline are both frequent manifestations in multiple sclerosis (MS). The Symbol Digit Modalities Test (SDMT) is the most used cognitive test in MS patients and relies on visual scanning. The purpose of this study was to investigate the influence of abnormal eye movements in INO on the SDMT score in MS patients.
MethodesIn this retrospective, observational, cross-sectional study, data of 199 MS patients from the Amsterdam MS cohort were analyzed. The presence of INO was detected using infrared oculography. All patients underwent a neurological and neuropsychological examination, an MRI scan, and an OCT scan. Using multiple linear regression analyses, the influence of INO on the SDMT score and other neuropsychological tests was studied.
ResultatenIn 62 patients, the diagnosis of INO was made. The SDMT score was significantly lower in the INO group compared to the non-INO group. The corrected regression model with the VDI Pv/Am left (which is a parameter to detect right INO) shows a significant influence of a right INO on the SDMT score. Other cognitive tests were also significantly affected by INO.
ConclusieHalf of the patients with a right INO scored clinically significantly worse on the SDMT due to their eye movement disorder. This means that the SDMT score reflects disturbed eye movements in addition to cognition. Caution should be exercised in interpreting the SDMT score if a right INO is present. We emphasize the importance of the detection of INO in neuro-ophthalmological examinations, given important implications in other domains of medicine.
BelangenverstrengelingNee
Auteurs 1
NaamKEYTSMAN
InitialenE
InstituutVrije Universiteit Brussel
StadJette
Auteurs 2
NaamHof
InitialenS
InstituutMS Centre
StadAmsterdam
Auteurs 3
NaamVan Lint
InitialenM
InstituutUniversity Hospital Brussel
StadJette
Auteurs 4
NaamStrijbis
InitialenE
InstituutMS Centre
StadAmsterdam
Auteurs 5
NaamSchoonheim
InitialenM
InstituutMS Centre
StadAmsterdam
Auteurs 6
NaamVan Schependom
InitialenJ
InstituutAI-supported modeling in clinical sciences, VUB
StadJette
Auteurs 7
NaamVan Oosten
InitialenB
InstituutMS Centre
StadAmsterdam
top ^