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Type presentatieE-poster
TitelShort-Term Clinical Outcomes of Patients with Diabetic Macular Edema Following a Therapy Switch to Faricimab
DoelWe investigated short-term clinical outcomes in patients with diabetic macular edema (DME) after switching to intravitreal Faricimab (IVF).
MethodesA retrospective chart review was conducted on DME patients who showed insufficient responses to prior therapy and were switched to IVF. Data included patient demographics, medical history, best-corrected visual acuity (BCVA), central retinal thickness (CRT) and central retinal volume (CRV). Functional and structural changes were analyzed, Faricimab responders and reduced responders were compared and factors influencing follow-up BCVA and CRT were assessed.
Resultaten25 eyes from 16 patients were included. After switching to IVF, mean BCVA showed no improvement, changing from 59.4±13.4 to 61.4±12.8 ETDRS letters (p=0.26). CRT reduced from 414.4±126.3 µm to 353.3±131.1 µm (p<0.011) and CRV decreased from 2.8±0.5 mm³ to 2.6±0.6 mm³ (p<0.012). Seven patients met responder criteria with at least a 5 ETDRS letter gain and 30 µm CRT reduction. Higher baseline BCVA (p<0.001) was associated with better BCVA post-IVF and higher baseline CRT (p<0.003), greater number of prior anti-VEGF agents (p<0.034) and prior corticosteroid injections (p<0.019) were linked to greater CRT at follow-up.
ConclusieFollowing the initial IVF series, anatomical improvements were observed, though no significant functional improvement was noted, with visual acuity remaining stable. Baseline BCVA, CRT, number of prior anti-VEGF agents and corticosteroid injections influenced post-IVF outcomes.
BelangenverstrengelingNee
Auteurs 1
NaamWOLFRUM
InitialenP
InstituutUniversity Medical Center of the Johannes Gutenberg-University
StadMainz
Auteurs 2
NaamStoffelns
InitialenB
InstituutUniversity Medical Center of the Johannes Gutenberg-University
StadMainz
Auteurs 3
NaamPfeiffer
InitialenN
InstituutUniversity Medical Center of the Johannes Gutenberg-University
StadMainz
Auteurs 4
NaamKorb
InitialenC
InstituutUniversity Medical Center of the Johannes Gutenberg-University
StadMainz
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