THE BELGIAN OPHTHALMIC ASSOCIATIONS
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| Type presentatie | Oral presentation |
| Titel | Evaluation of tear film osmolarity changes after corneal refractive surgery and comparison between two tear substitutes |
| Doel | To evaluate tear osmolarity and dry eye disease (DED) symptoms (OSDI questionnaire) changes after corneal refractive surgery and compare evolution of these parameters between 2 different concentrations of sodium hyaluronate (SH)tear sustitute(TS) |
| Methodes | Tear osmolarity and OSDI were measured before and 1,7 and 30 days after a surgery.Patients were divided in 2 groups according to the prescribed TS.10 patients received 0.3% SHTS(NeovisGel Multi,HorusPharma) and 10 patients received 0.2% SHTS(HyloGel,Ursapharm) |
| Resultaten | We included 40 eyes from 20 consecutive patients.In the overall population,we observed no significant difference between preoperative and any postoperative values of osmolarity (307.0, 304.5, 303.5, 304.2mOsm/L at day0, 1, 7 and 30,respectivelly).OSDI worsened at day 7(10.5 to 27.4;p=0.002) with no difference at day 30.When comparing 0.2% SH and 0.3% SH groups,tear osmolarity and OSDI were not significantly different at any time.However, evolution was different between groups when compared to baseline.Osmolarity dropped at day 1 in 0.2% SH group and went back to preoperative values at day 30.In 0.3% SH group,osmolarity decreased at day 7 and reached significance at day 30(301.72;p=0.02). Regarding OSDI,0.2% SH group showed a significant worsening after 7 days with no difference after 30 days.In 0.3% SH group, OSDI showed no significant variation |
| Conclusie | Our study showed no significant increase in osmolarity after refractive surgery.After 30days, osmolarity was significantly lower than baseline in 0.3% SH group with no difference in 0.2% SH group.The results of this study indicate that higher concentration of SH and lower osmolarity could improve parameters of DED post refractive surgery.Larger studies are needed to confirm our findings |
| Belangenverstrengeling | Nee |
Auteur 1
| Naam | CRAHAY |
| Initialen | F |
| Instituut | Citadelle |
| Stad | Liège |
Auteur 2
| Naam | Papart |
| Initialen | S |
| Instituut | Citadelle |
| Stad | Liège |