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Type presentatieE-poster
TitelComparison of Scheimpflug Corneal Tomography and Anterior Segment Optical Coherence Tomography measurements in Corneal Cystinosis
DoelTo report the clinical course and compare the utility of Scheimpflug tomography (ST) and Anterior Segment Optical Coherence Tomography (AS-OCT) for central corneal thickness (CCT) and corneal densitometry (CD) assessment in patients with corneal crystals due to nephropathic cystinosis.
MethodesA retrospective chart analysis of 3 patients with nephropathic cystinosis, and the presence of corneal cystine crystals in both eyes was performed. All patients underwent clinical examination, as well as anterior segment photography, ST (Pentacam HR), and AS-OCT (CASIA2) scans. CD was exported from built-in proprietary software for ST and from custom-made validated software for AS-OCT. AS-OCT images were rescaled to grayscale units from 0 (maximum transparency) to 100 (minimum transparency) to match built-in ST densitometry readings. Further, the mean pixel intensity, representative of CD, was calculated from the pixels corresponding to the segmented cornea.
ResultatenAll three patients had pathognomonic cystine crystals deposits in the cornea and were treated with cysteamine medications that resulted in clinical improvement. Both examinations could be performed but in the more severe cases, AS-OCT showed far greater utility to estimate CD. In four out of six eyes examined, ST showed disproportionate CCT values, compared to the AS-OCT, while reliable CD measurements were only available in AS-OCT.
ConclusieThe AS-OCT should be considered a baseline ocular measurement in cystinosis and in the evaluation of disease progression and treatment efficacy.
BelangenverstrengelingNee
Auteur 1
NaamVERCAUTEREN
InitialenL
InstituutAntwerp University Hospital
StadAntwerp
Auteur 2
NaamConsejo
InitialenA
InstituutUniversity of Zaragoza
StadZaragoza
Auteur 3
NaamDe Vries
InitialenMJ
InstituutAntwerp University Hospital
StadAntwerp
Auteur 4
NaamKrolo
InitialenI
InstituutUniversity Hospital Brussels
StadBrussels
Auteur 5
NaamKoppen
InitialenC
InstituutAntwerp University Hospital
StadAntwerp
Auteur 6
NaamNi Dhubhghaill
InitialenS
InstituutUniversity Hospital Brussels
StadBrussels
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