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Type presentatieE-poster
TitelSARS-CoV-2 RNA detection in conjunctival swabs and ocular surface manifestations of patients hospitalized for COVID-19 pneumonia: a Belgian cohort.
DoelTo investigate the presence of SARS-CoV-2 in the tears of hospitalized COVID-19 patients and to assess systemic and ophthalmic clinical characteristics in a Belgian cohort
MethodesProspective study of adult patients hospitalized for COVID-19 pneumonia confirmed by a chest computer tomography (CT) with no recent diagnosis or exacerbation of an ocular pathology. After completing an ocular symptom questionnaire, the patients underwent a macroscopic ocular exam and a conjunctival swab. A reverse transcriptase polymerase chain reaction (RT-PCR) was performed on the swabs to identify SARS-CoV-2 RNA. Clinicobiological data and PCR results of both ocular and nasopharyngeal samples were collected.
ResultatenTwo patients of 58 (3,45%) had a positive conjunctival PCR: one with <10E3 copies/ml, the second highly positive with >=10E3 - <10E5 copies/ml. None of them had ocular symptoms. 13 patients (22%) presented ocular symptoms such as tearing (69,23%), redness (53,85%), burning 38% or itching 15,38%. Linear regression found that there was a significant statistical correlation between the presence of ocular and neurological symptoms (p= 0,021).
ConclusieIt is possible to find tear fluids with a high viral load but the probability of this occurrence appears to be rather low. The presence of SARS-CoV-2 in tears was however not associated with the presence of symptoms in this study. Ocular symptoms may not be related to the presence of the virus itself.
BelangenverstrengelingNee
Auteur 1
NaamVALYI
InitialenZ
InstituutCHU Saint Pierre, Ophtalmologie
StadBruxelles
Auteur 2
NaamKhalil
InitialenM
InstituutCHU Saint Pierre, Ophtalmologie
StadBruxelles
Auteur 3
NaamVan Den Wijngaert
InitialenS
InstituutLaboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB), Microbiologie
StadBruxelles
Auteur 4
NaamKonopnicki
InitialenD
InstituutCHU Saint Pierre, Maladies Infectieuses
StadBruxelles
Auteur 5
NaamWillermain
InitialenF
InstituutCHU Saint Pierre, Ophtalmologie
StadBruxelles
Auteur 6
NaamBruyneel
InitialenM
InstituutCHU Saint Pierre, Pneumologie
StadBruxelles
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