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Type presentatieE-poster
TitelNormal tension glaucoma: a dynamic optical coherence tomography angiography study.
DoelVascular dysregulation seems to play a role in the pathogenesis of glaucoma, especially normal tension glaucoma (NTG). The development of optical coherence tomography angiography (OCT-A) enabled measurement of the retinal microvasculature with high repeatability. Nonetheless, only a few studies transformed OCT-A into a dynamic exam employing a sympathomimetic stimulus. The goal of this study was to use this dynamic OCT-A exam (1) to differentiate healthy individuals from glaucoma patients and (2) to distinguish glaucoma subcategories, NTG and high-tension primary open angle glaucoma (POAG).
MethodesRetinal vessel density (VD) in NTG patients (n=16), POAG patients (n=12) and healthy controls (n=14) was compared before and during a hand grip test with a hydraulic dynamometer.
ResultatenAt baseline, peripapillary VD was lower in POAG and NTG compared to healthy controls and slightly higher in NTG compared to POAG when corrected for mean arterial pressure (MAP). Peripapillary and macular (superficial and deep) VD differences were found for gender, age and baseline MAP. No change in VD occurred (pre/post stimulus) in any of the groups.
ConclusieRetinal VD loss in glaucoma patients was confirmed and the necessity to correct for gender, age and especially MAP was proven. Although replication in a larger population is necessitated, OCT-A might not be the most suitable method to dynamically evaluate the retinal microvasculature.
BelangenverstrengelingNee
Details verstrengelde belangenNA
Auteur 1
NaamVAN EIJGEN
InitialenJ
InstituutUZ Leuven / KU Leuven
StadLeuven
Auteur 2
NaamHeintz
InitialenA
InstituutUZ Leuven / KU Leuven
StadLeuven
Auteur 3
NaamVan der Pluijm
InitialenC
InstituutUZ Leuven / KU Leuven
StadLeuven
Auteur 4
NaamDelporte
InitialenK
InstituutKU Leuven
StadLeuven
Auteur 5
NaamDe Witte
InitialenD
InstituutKU leuven
StadLeuven
Auteur 6
NaamMolenberghs
InitialenG
InstituutKU Leuven
StadLeuven
Auteur 7
NaamBarbosa-Breda
InitialenJ
InstituutUniversity of Porto
StadPorto
Auteur 8
NaamStalmans
InitialenI
InstituutUZ Leuven / KU Leuven
StadLeuven
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