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TitelEvaluation of ganglion cells loss in anterior ischaemic optic neuropathies
DoelTo analyse the loss of thickness of ganglion cell complex (GCC, inner plexiform layer and ganglion cell layer) in patients with non-arteritic anterior ischaemic optic neuropathy (NA-AION).
MethodesThis retrospective study enrolled 32 eyes (28 patients) with NA-AION and 28 fellow eyes, considered as controls, between 2014 and 2020. A complete examination with visual field (VF), visual acuity (VA) and optical coherence tomography was performed at baseline and after 1, 3 and 6 months. Retinal nerve fibre layer (RNFL) and GCC layer thickness were evaluated at each visit.
ResultatenA total of 28 patients were included in the analysis, with a mean age of 59±11 years (57.1% were male). At presentation, mean (±SD) RNFL thickness in patients with NA-AION was 227.4 (±72.1) and 92,6 µm (±9.0) in the fellow eyes (p<0.05). At 6 months, a significant decrease was observed in the pathologic eyes (64.9 (±10.4) µm). GCC layer thickness at presentation and at 6 months in the NA-AION eyes were 60.3 ± 24.4 and 61.9 ±10.4 µm, respectively, a non significant difference. When compared to the fellow eyes (80.4±6.5, p<0,0001), we observed a significant reduction of the GCC thickness corresponding to a loss of 24.3% in average (range: 5-42.6%). Moreover, a negative correlation (r=-0,64) is observed between the VF defect and the GCC thickness.
ConclusieAfter an episode of NA-AION, we observed a significant decrease of GCC thickness compared to the fellow eye, which is correlated to the visual field defect.
BelangenverstrengelingNee
Auteur 1
NaamCHAPELLE
InitialenA
InstituutCHU de Liège
StadLiège
Auteur 2
NaamRAKIC
InitialenJM
InstituutCHU de Liège
StadLiège
Auteur 3
NaamPLANT
InitialenGT
InstituutMoorfields Eye Hospital
StadLondon
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