Titel | Clinical impact of 18F-FDG PET CT in the work up of children with uveitis. |
Doel | To evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) in the work up of paediatric uveitis. |
Methodes | We performed a retrospective study of 12 children followed for uveitis who underwent whole body 18F-FDG PET/ultra low dose CT between 2011 and 2019. |
Resultaten | The average patients’ age was 11 years. 100% of patients presented bilateral uveitis, 50% panuveitis and 92% (11/12) had choroidal involvement. 5 of the 12 (42%) patients showed abnormal 18F-FDG uptake on their 18F-FDG PET/CT, including 3 with pathognomonic images of active granulomatous diseases. A biopsy was performed in one of these patients (consistent with sarcoidosis) and in the two others with abnormal 18F-FDG uptake without pathognomonic images of granulomatous disease (one consistent with sarcoidosis, the other negative). Final uveitis diagnosis were idiopathic in 58% of the patients, ocular sarcoidosis in 17% (2/12), TINU in 16,6% (2/12) and tubercular uveitis in 8,3% (1/12). |
Conclusie | In this small series, 18F-FDG PET/CT provided important information for uveitis diagnosis in approximatively 30 % (4/12) of our patients. Further studies are needed to define the exact place of 18F-FDG PET/CT and chest CT in the work-up of paediatric uveitis. |
Belangenverstrengeling | Nee |
Naam | EL MOUDEN |
Initialen | J |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |
Naam | Bazewicz |
Initialen | M |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |
Naam | Makhoul |
Initialen | D |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |
Naam | Goffin |
Initialen | L |
Instituut | Pediatric Immuno-Rheumatology - CHU HUDERF - ULB |
Stad | Bruxelles |
Naam | Judice |
Initialen | L |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |
Naam | Caspers |
Initialen | L |
Instituut | Ophthalmology - CHU St-Pierre - ULB |
Stad | Bruxelles |
Naam | Draganova |
Initialen | D |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |
Naam | Garcia |
Initialen | C |
Instituut | Nuclear Medicine - CHU St-Pierre - ULB |
Stad | Bruxelles |
Naam | Willermain |
Initialen | F |
Instituut | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
Stad | Bruxelles |