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TitelAssessment of structural neurovascular coupling of radial peripapillary capillary in neovascular age dependent macular degeneration
DoelTo study structural neurovascular coupling of radial peripapillary capillary (RPC) in neovascular age dependent macular degeneration (nAMD), using optical coherence tomography angiography.
MethodesA cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density and retinal nerve fiber layer thickness were obtained to analyse their correlation. Linear and multiple linear regression models were used.
ResultatenWe included 36 eyes (n = 18 control; n = 18 nAMD from 36 subjects (mean [SD] age 74.05 [7.4] years). When compared with controls, no significant difference was found in annular RPC density and retinal nerve fiber layer thickness. (RPC density: P = 0.299; RNFL: P = 0.365). In eyes with neovascular age-dependent macular degeneration, RPC density and retinal nerve fiber layer thickness correlated significantly (linear regression: R2 = 0.226, P = 0.016). After correction for sex, best-corrected visual acuity, eye pressure, age, spherical equivalent and number of injection, this correlation was still significant. In the control eyes, no such correlation was found.
ConclusieAlthough, no significant differences in RPC density and RNFL thickness were found, these parameters did correlate significantly in nAMD. This correlation was not found in control eyes. Their significance in the pathophysiology warrants further research.
BelangenverstrengelingNee
Auteur 1
NaamNELIS
InitialenP
InstituutUZBrussel (VUB)
StadBrussels
Auteur 2
NaamTen Tusscher
InitialenM
InstituutUZBrussel (VUB)
StadBrussels
Auteur 3
NaamEter
InitialenN
InstituutUniversitätsaugenklinik Münster
StadMuenster
Auteur 4
NaamAlnawaiseh
InitialenM
InstituutUniversitätsaugenklinik Münster
StadMuenster
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