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TitelCancer-associated rethinopathy secondary to gallbladder carcinoma
DoelPresenting a case report of a patient with cancer-associated retinopathy (CAR) secondary to a gallbladder carcinoma.
MethodesThe diagnosis of CAR was suspected on grounds of anamnesis, clinical features and technical investigations (VF, OCT, FF-ERG, PET-CT, immunofluorescence antibody screening). Initial treatment consisted of high dose corticosteroids (1mg/kg/day)
ResultatenA positive clinical evolution was found after treatment with high-dose corticoids with disappearance of uveitis symptoms and gradual improvement of visual acuity and VF.
ConclusieCAR is a rare disease entity caused by auto-antibodies against retinal antigens. The disease is associated with a wide spectrum of malignancies. Clinical features are progressive VF narrowing, diminished visual acuity, macular edema, vitritis, fundus changes, photophobia, diminished color perception. Cortisone therapy with or without plasmapheresis can be considered as a first choice treatment. Corticoid saving immunosuppressive therapy and/or biologicals can be used as maintenance therapy. The long term prognosis is uncertain because further evolution is possible.
BelangenverstrengelingNee
Auteur 1
NaamGOYVAERTS
InitialenK
InstituutUniversiteit Antwerpen
StadWilrijk
Auteur 2
NaamVAN LINT
InitialenM
InstituutUniversitair Ziekenhuis Antwerpen
StadEdegem
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