Abstract bekijken

Deze abstract is toegekend aan sessie AOB e-Posters
TitelVisual rehabilitation using a scleral contact lens following cultivated limbal stem cell transplantation.
DoelTo describe a case of unilateral total limbal stem cell deficiency (LSCD) resolved by ocular surface reconstruction using cultured autologous limbal stem cells, corneal transplant and a scleral lens. To our knowledge, this is the first documented case of scleral lens usage in this pathology.
MethodesA 55-year-old, HIV-positive male suffered a unilateral alkali burn 16 years ago, resulting in a total LSCD. The patient had received a previous penetrating keratoplasty (PK) that ultimately failed to impede corneal conjunctivalization. Upon referral, diagnosis of LSCD was made on clinical grounds. We elected to perform an ex-vivo cultivated limbal epithelial stem cell transplantation (CLET) using a small limbal graft from the contralateral, healthy eye. To remove deep stromal scarring, the patient received a second PK one year after transplantation. One year later, the patient was fitted with a scleral lens.
ResultatenOne year after PK, the patient’s vision had improved from hand movements initially to 0.5 with optimal correction, and the ocular surface was stable with a transparent corneal graft. Using a scleral lens, the patient’s best-corrected vision improved significantly from 0.5 to 1.0.
ConclusieThis case illustrates the fact that CLET can be successfully utilized to restore a stable corneal surface with consequent improvement in visual acuity, and this in cases of severe total LSCD such as chemical burns. Furthermore, it also highlights the beneficial role of scleral lenses to achieve excellent functional outcomes in these patients.
BelangenverstrengelingNee
Auteur 1
NaamBALLET
InitialenB
InstituutUniversitair Ziekenhuis Antwerpen
StadAntwerpen
Auteur 2
NaamBEHAEGEL
InitialenJ
InstituutUniversitair Ziekenhuis Brussel
StadBrussel
Auteur 3
NaamNI DHUBHGHAILL
InitialenS
InstituutUniversitair Ziekenhuis Antwerpen
StadAntwerpen
top ^