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TitelFractal dimension of the retinal vasculature: age-related evolution in the general population
DoelTo investigate the age-related evolution of the fractal dimension (FD) of the retinal vascular network in a large cohort of healthy individuals with a wide age range.
MethodesA total of 838 disc-centered fundus images of 838 individuals (53% female and 47% male) were collected, aiming at approximately 100 subjects in every 10-year age group between 0 and 99 years. IFLEXIS, software for semi-automated retinal vessel analysis, was used for vessel segmentation and retinal vascular fractal analysis, using the box counting method. The region of interest (ROI) was the annulus between 1.5 and 5 times the radius of the optic disc, centered on the optic disc.
ResultatenA mean FD of 1.399 (± 0.038) was observed. A decreasing FD of the retinal vasculature was observed with aging , which was statistically significant (p < 0,0005). The mean values (± SD) of the FD per age group were 1.452 (± 0.045) in 0-9 years old, 1.421 (± 0.041) in 10-19 years, 1.399 (± 0.031) in 20-29 years, 1.396 (± 0.029) in 30-39 years, 1.395 (± 0.032) in 40-49 years, 1.393 (± 0.031) in 50-59 years, 1.387 (± 0.031) in 60-69 years, 1.389 (± 0.031) in 70-79 years, 1.383 (± 0.031) in 80-89 years and 1.370 (± 0.025) in the 90-99 years age group. FD was not significantly correlated with gender.
ConclusieThis study demonstrates that the retinal vasculature undergoes age-related rarefaction with age, which is already detectable at a young age.
BelangenverstrengelingNee
Auteur 1
NaamLEMMENS
InitialenS
InstituutKU Leuven, UZ Leuven
StadLeuven
Auteur 2
NaamLandtmeters
InitialenC
InstituutKU Leuven
StadLeuven
Auteur 3
NaamPeeters
InitialenR
InstituutKU Leuven
StadLeuven
Auteur 4
NaamSimons
InitialenAS
InstituutKU Leuven
StadLeuven
Auteur 5
NaamVercauteren
InitialenJ
InstituutKU Leuven
StadLeuven
Auteur 6
NaamVan Keer
InitialenK
InstituutKU Leuven, UZ Leuven
StadLeuven
Auteur 7
NaamDe Boever
InitialenP
InstituutVITO
StadMol
Auteur 8
NaamStalmans
InitialenI
InstituutKU Leuven, UZ Leuven
StadLeuven
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