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TitelThe eye at high altitude
Abstract Nr.2077
DoelTo investigate the response and recovery of retro-bulbar, choroidal and retinal circulations to exposure to normobaric hypoxia in healthy individuals.
MethodesParticipants were examined with Optical Coherence Tomography (OCT), angio-OCT, retinography and colour Doppler imaging before, during and after a six-hour exposure to a simulated height of 4000m in a high-altitude chamber. Retinal nerve fiber layer (RNFL) and choroidal thickness (CT) were measure and vessel density was quantified as the mean gray value on angio-OCT images. Central retinal arteriolar (CRAE) and venular (CRVE) equivalent were measured on retinographies. Repeated measures ANOVA was used to assess the changes within patients over time.
Resultaten18 eyes of 18 healthy individuals aged 34.5±16.4 years were analyzed. RNFL, CT, peripapillary vessel density and CRVE showed a significant increase after six hours of hypoxia exposure (p = 0.036, p < 0.001, p = 0.040 and p <0.001 respectively) that was accompanied by a decrease in resistive and pulsatility indexes (both p<0.001) and an increase in ophthalmic artery flow velocities (p < 0.001). After one hour of recovery at sea level, all these changes returned to baseline values.
ConclusieTo the best of our knowledge, this study stands as one of the most exhaustive studies on changes in ocular blood flow in response to prolonged hypoxia. We demonstrate that in healthy individuals the decrease in ambient oxygen saturation at high altitudes is compensated at the retrobulbar, choroidal and retinal micro- and macrocirculatory levels and that these changes quickly recover back to baseline.
BelangenverstrengelingNee
Auteur 1
NaamVAN KEER
InitialenK
InstituutUZ Leuven
StadLeuven
Auteur 2
NaamBarbosa Breda
InitialenJ
InstituutUZ Leuven
StadLeuven
Auteur 3
NaamDe Jongh
InitialenR
InstituutZOL
StadGenk
Auteur 4
NaamNijs
InitialenI
InstituutZOL
StadGenk
Auteur 5
NaamWirix
InitialenM
InstituutZOL
StadGenk
Auteur 6
NaamAbegão Pinto
InitialenL
InstituutCentro Hospitalar Lisboa Norte
StadLisbon
Auteur 7
NaamStalmans
InitialenI
InstituutUZ Leuven
StadLeuven
Auteur 8
NaamVandewalle
InitialenE
InstituutUZ Leuven
StadLeuven
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