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Titel	Quantification of changes in foveal capillary architecture induced by idiopathic epiretinal membrane using OCT-Angiography
Abstract Nr.	2073

Doel	To quantify the extent and depth of distortion of the foveal capillary architecture due to traction of idiopathic epiretinal membrane (ERM) using optical coherence tomography angiography (OCT-A).
Methodes	Multimodal imaging including OCT-A (Angiovue, Optovue) was performed in 42 eyes with idiopathic ERM (72.4 years +/-6.8). Based on 6x6mm2 OCT-A images, a macular vessel density ratio (MVR=VDfo [Vessel density foveal region]/VDp [vessel density parafoveal region]) was calculated for the superficial (s), deep (d) and full-thickness (f) slabs to assess a depth-resolved, non-invasive evaluation of foveal distortion. The acquired data were subdivided in a patient group with mild and severe BCVA reduction due to ERM. Data was compared to age-matched healthy controls.
Resultaten	In all three slabs, MVR was significantly smaller in the control group in comparison with the ERM group: MVRs: 0.63 +/- 0,1 vs 0.83 +/- 0.1 (p>0.001); MVRd: 0.60 +/- 0.1 vs 0.73 +/- 0.1 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.82 +/- 0.1 (p<0.001). Group 1 (BCVA <0.4 LogMar) showed a significantly higher MVR in comparison with the control group in the superf. plexus only: MVRs: 0.64 +/- 0.1 vs 0.78 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.65 +/- 0.2 (p=0.3); MVRf: 0.68 +/- 0.1 vs 0.77 +/- 0.1 (p=0.01). However, group 2 (BCVA >= 0.4 LogMar) showed a significantly higher MVR in all three slabs: MVRs: 0.64 +/- 0.1 vs 0.86 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.77 +/- 0.2 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.85 +/- 0.1 (p<0.001).
Conclusie	Assessing MVR using OCT-A may serve as a tool to quantify the extent and depth of distortion of the foveal capillary architecture due to traction of ERM.
Belangenverstrengeling	Nee

Auteur 1

Naam	NELIS
Initialen	P
Instituut	UKM, UZB
Stad	Muenster, Brussels

Auteur 2

Naam	Alten
Initialen	F
Instituut	UKM
Stad	Muenster

Auteur 3

Naam	Clemens
Initialen	C
Instituut	UKM
Stad	Muenster

Auteur 4

Naam	Heiduschka
Initialen	P
Instituut	UKM
Stad	Muenster

Auteur 5

Naam	Van Lint
Initialen	M
Instituut	UZB
Stad	Brussels

Auteur 6

Naam	Ten Tusscher
Initialen	M
Instituut	UZB
Stad	Brussels

Auteur 7

Naam	Eter
Initialen	N
Instituut	UKM
Stad	Muenster