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TitelLong-term results of standardized, non-xenogenic, cultivated limbal epithelial stem cell transplantations.
Abstract Nr.3004
DoelTo evaluate the long-term success rate of transplanted non-xenogenic, bio-engineered, composite grafts of cultured limbal epithelial cells on standardized amniotic membranes in patients with limbal stem cell deficiency.
MethodesWe report the extended outcome of standardized cultivated limbal stem cell transplantations of a phase I/II clinical trial. Between July 2008 and May 2012, 21 patients with partial (n=3) or total (n=18) limbal stem cell deficiency received either autologous (n=15) or allogenic (n=6) stem cell grafts, using a protocol free from xenogenic products and a reduced manipulation surgical technique. The outcome measures were compared with short-term results (mean follow-up of 22 months) of the same trial, in which a 67% success rate was seen.
ResultatenFive patients were lost to follow-up and 2 patients were excluded because of unrelated side effects. The remaining 14 patients had a mean follow-up of 68 months (range 29-100 months). Of these, 7 (50%) patients were graded as anatomical success. Three of the 7 patients retained a persistent intact epithelium without corneal neovascularization and were subclassified as ‘total’ anatomical success. Four of the 7 patients were subclassified as ‘partial’ anatomical success meaning a complete epithelialization with a mild revascularization, but less than ad admission. There was no significant improvement of visual acuity, pain or photophobia in the total cohort.
ConclusieCultivated limbal epithelial stem cell transplantation offers a safe alternative in the reconstruction of the anterior cornea. However, compared to early post-operative results, there is a decline of anatomical and functional success over time.
BelangenverstrengelingNee
Auteur 1
NaamBEHAEGEL
InitialenJ
InstituutUZA
StadEdegem
Auteur 2
NaamNí Dhubhghaill
InitialenS
InstituutUZA
StadEdegem
Auteur 3
NaamKoppen
InitialenC
InstituutUZA
StadEdegem
Auteur 4
NaamLeysen
InitialenI
InstituutUZA
StadEdegem
Auteur 5
NaamTassignon
InitialenMJ
InstituutUZA
StadEdegem
Auteur 6
NaamZakaria
InitialenN
InstituutUZA
StadEdegem
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