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Deze abstract is toegekend aan sessie FRO: Fund for Research in Ophthalmology
TitelFRO: Rho Kinase Inhibitor AMA0526 Improves Surgical Outcome in a Rabbit Model of Glaucoma Filtration Surgery
Abstract Nr.1032
DoelTo elucidate the effect of a locally acting, selective ROCK inhibitor on the wound healing process and surgical outcome of glaucoma filtration surgery.
MethodesThe in vivo effect of topical AMA0526 0.3% TID was investigated in a rabbit model of glaucoma filtration surgery. Treatment outcome was studied by clinical investigation of the bleb area as well as immunohistological analyses for inflammation, angiogenesis and collagen deposition at day 8, 14 and 30 after surgery. Vehicle was used as control in seperate groups.
ResultatenAMA0526 significantly improved bleb area and survival compared to vehicle treated eyes. Immunohistological analyses showed significant reduction of inflammation, angiogenesis and collagen deposition after treatment with the ROCK inhibitor. Compared to vehicle, inflammation was decreased by 33% at 8 days, angiogenesis was reduced by 52% on day 8 and by 29% at 14 days, and collagen deposition by 30% on surgical day 30.
ConclusieThis study shows that AMA0526 is able to improve glaucoma surgery outcome in rabbits. In addition to improved bleb area, AMA0526 led to decreased inflammation, angiogenesis and fibrosis. This study can open new perspectives for a safer and more efficient glaucoma surgery.
Auteur 1
NaamVAN DE VELDE
InitialenS
InstituutKUL
StadLeuven
Auteur 2
NaamVan Bergen
InitialenT
InstituutKUL
StadLeuven
Auteur 3
NaamVandewalle
InitialenE
InstituutKUL/UZ
StadLeuven
Auteur 4
NaamCastermans
InitialenK
InstituutAmakem
StadDiepenbeek
Auteur 5
NaamKindt
InitialenN
InstituutAmakem
StadDiepenbeek
Auteur 6
NaamMoons
InitialenL
InstituutKUL
StadLeuven
Auteur 7
NaamStalmans
InitialenI
InstituutKUL/UZ
StadLeuven
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