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Titel24h IOP control by subchronic AMA0076 in Dutch Belted Rabbits
Abstract Nr.P121
DoelTo investigate IOP lowering efficacy of rho kinase (ROCK) inhibitors after subchronic treatment.
MethodesDBR (5 rabbits/concentration) were treated daily with a single topical dose of AMA0076 or Y-39983 in a masked fashion for 14 days. Saline was used as control in the contralateral eye. IOP was measured before, 3 and 7 hours after treatment. AMA0076 is a locally acting ROCK inhibitor, developed by Amakem Ophthalmics, to reduce side effects such as hyperemia.
ResultatenMean baseline IOP before start of experiment was 21.0 ± 0.4 and 20.7 ± 0.4 mmHg for AMA0076 and Y-39983, respectively. Significant IOP reduction was observed in all treatment groups. A maximal IOP reduction of 39 and 35% was reached with AMA0076 0.1% and Y-39983 0.05%, respectively. Initially, IOP returned to baseline values 24h after administration of AMA0076. After 3 days of treatment with AMA0076 a sustained IOP lowering effect was present: IOP did not return to baseline values, but remained significantly lower for all concentrations of AMA0076. Treatment with Y-39983 did not show this sustained IOP decrease. As a result of this sustained IOP lowering effect smaller IOP fluctuations were observed in animals treated with AMA0076 compared to Y-39983. Hyperemia was observed with all concentrations of Y-39983 whereas only mild hyperemia was induced after administration of AMA0076 0.4.
ConclusieTreatment of rabbits with AMA0076 resulted in IOP reduction that was more sustained and associated with smaller peak-through fluctuations than Y-39983.
Auteur 1
NaamVAN DE VELDE
InitialenS
InstituutKUL Ophthalmo
Stadleuven
Auteur 2
NaamVan Bergen
InitialenT
InstituutKUL Ophthalmo
StadLeuven
Auteur 3
NaamHollanders
InitialenK
InstituutKUL Ophthalmo
StadLeuven
Auteur 4
NaamSijnave
InitialenD
InstituutKUL Ophthalmo
StadLeuven
Auteur 5
NaamVandewalle
InitialenE
InstituutKUL Ophthalmo
StadLeuven
Auteur 6
NaamCastermans
InitialenK
InstituutAmakem Ophthalmics
StadDiepenbeek
Auteur 7
NaamKindt
InitialenN
InstituutAmakem Ophthalmics
StadDiepenbeek
Auteur 8
NaamMoons
InitialenL
InstituutKUL Biologie
StadLeuven
Auteur 9
NaamLeysen
InstituutAmakem Ophthalmics
StadDiepenbeek
Auteur 10
NaamStalmans
InitialenI
InstituutKUL Ophthalmo
StadLeuven
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