Titel | 24h IOP control by subchronic AMA0076 in Dutch Belted Rabbits |
Abstract Nr. | P121 |
Doel | To investigate IOP lowering efficacy of rho kinase (ROCK) inhibitors after subchronic treatment. |
Methodes | DBR (5 rabbits/concentration) were treated daily with a single topical dose of AMA0076 or Y-39983 in a masked fashion for 14 days. Saline was used as control in the contralateral eye. IOP was measured before, 3 and 7 hours after treatment. AMA0076 is a locally acting ROCK inhibitor, developed by Amakem Ophthalmics, to reduce side effects such as hyperemia. |
Resultaten | Mean baseline IOP before start of experiment was 21.0 ± 0.4 and 20.7 ± 0.4 mmHg for AMA0076 and Y-39983, respectively. Significant IOP reduction was observed in all treatment groups. A maximal IOP reduction of 39 and 35% was reached with AMA0076 0.1% and Y-39983 0.05%, respectively. Initially, IOP returned to baseline values 24h after administration of AMA0076. After 3 days of treatment with AMA0076 a sustained IOP lowering effect was present: IOP did not return to baseline values, but remained significantly lower for all concentrations of AMA0076. Treatment with Y-39983 did not show this sustained IOP decrease. As a result of this sustained IOP lowering effect smaller IOP fluctuations were observed in animals treated with AMA0076 compared to Y-39983. Hyperemia was observed with all concentrations of Y-39983 whereas only mild hyperemia was induced after administration of AMA0076 0.4. |
Conclusie | Treatment of rabbits with AMA0076 resulted in IOP reduction that was more sustained and associated with smaller peak-through fluctuations than Y-39983. |
Naam | VAN DE VELDE |
Initialen | S |
Instituut | KUL Ophthalmo |
Stad | leuven |
Naam | Van Bergen |
Initialen | T |
Instituut | KUL Ophthalmo |
Stad | Leuven |
Naam | Hollanders |
Initialen | K |
Instituut | KUL Ophthalmo |
Stad | Leuven |
Naam | Sijnave |
Initialen | D |
Instituut | KUL Ophthalmo |
Stad | Leuven |
Naam | Vandewalle |
Initialen | E |
Instituut | KUL Ophthalmo |
Stad | Leuven |
Naam | Castermans |
Initialen | K |
Instituut | Amakem Ophthalmics |
Stad | Diepenbeek |
Naam | Kindt |
Initialen | N |
Instituut | Amakem Ophthalmics |
Stad | Diepenbeek |
Naam | Moons |
Initialen | L |
Instituut | KUL Biologie |
Stad | Leuven |
Naam | Leysen |
Instituut | Amakem Ophthalmics |
Stad | Diepenbeek |
Naam | Stalmans |
Initialen | I |
Instituut | KUL Ophthalmo |
Stad | Leuven |