THE BELGIAN OPHTHALMIC ASSOCIATIONS
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| Titre | Comparison of the IOP-lowering effects of xalatan versus generic latanoprost in normal subjects |
| Abstract Nr. | P112 |
| But | To compare the intraocular pressure (IOP)-lowering efficacy of Xalatan with generic latanoprost (Latanoprost EG) in normal healthy subjects, over a one-day/one-instillation period. |
| Méthodes | 20 normal subjects were recruited in this single-center, randomized, prospective, open label, two-period comparative study. At the baseline visit, subjects' baseline IOP was measured in both eyes at 8am in the morning. Subjects were then administered Xalatan in the right eye and Latanoprost EG in the left eye, both at 10pm, and IOP was controlled again the following morning at 8am (corresponding to the peak of action). Statistical analysis was performed with Wilcoxon's test and two-way ANOVA, as they were used to assess the level of IOP decrease significance in both groups. |
| Résultats | The baseline IOP in all the 20 subjects was: . The IOP decrease in the first group administered with Xalatan was 3.74 + 1.9 mmHg. The IOP pressure at baseline and 10 hours after Xalatan administration were respectively 14.33 + 2.1 mmHg and 10.59 + 3.9 mmHg. In the second group, eyes administered with Latanoprost EG showed a slighter IOP decrease from baseline 2.85 +/- 1.8 mmHg. The IOP at baseline and 10 hours after Latanoprost EG were respectively 14.01 + 2.37 mmHg and 11.45 + 2.39 mmHg. There was no statistically significant difference between both groups for decrease of IOP (p-value 0.148 with Wilcoxon's test and 0.117 for ANOVA). |
| Conclusion | This study showed that the magnitude of IOP lowering in normal healthy subjects with Xalatan and Latanoprost EG is not significantly different over a one-day/one-instillation period. Results could be expected to be different on glaucomatous patients over longer periods. |
Auteur 1
| Nom | QIN |
| Initiales | V |
| Institut | Cliniques Universitaires Saint Luc |
| Ville | Brussels |
Auteur 2
| Nom | Pourjavan |
| Initiales | S |
| Institut | Cliniques Universitaires Saint Luc |
| Ville | Brussels |